Humanity in a Dish


Wednesday, 24 June, 08:30-12:30
Stockholmsässan Room A4


Organized by:
Chad A. Cowan
Harvard University, USA


Genome-wide association studies have identified many common genetic variants that influence human health and disease. In this focus session we will bring together experts in stem cell biology and human genomics to discuss recent progress and challenges in developing cell based functional genomic assays at scale for common diseases in cohort studies, as well as highlight iPSC resources available for genomic research.

There will be two sessions:
Session I: COREdinates: stem cell core facilities group

Highlighting the roles that core facilities play in cell therapies and disease modeling applications, including the production and banking of iPSC cohorts.

   
Session Chair:

Mark Tomishima, Memorial Sloan Kettering Cancer Center, USA
8:30-8:50
Overview of COREdinates and preclinical development work for Parkinson’s consortia
Mark Tomishima, Memorial Sloan Kettering Cancer Center, USA
8:50-9:10
Essential 8™ Medium: New Application Horizons for Culturing Human Pluripotent Stem Cells (hPSCs)
Roland Leathers, Termo Fisher Scientific, USA
9:10-9:30
Are all iPSC created equal? A comparison of iPSC from different source tissue
Jennifer Moore, RUCDR, USA
9:30-9:50
Taming the beast; 5S practice applied to large scale iPS production
Chris Kirton, Sanger Institute, United Kingdom
9:50-10:10
Realizing the Potential: Ensuring Accessibility of Cell Line and Data Resources
Tenneilee Ludwig, WiCell, USA





Session II: The functional annotation of human genetic variants

Highlighting ongoing efforts in several labs to use large cohorts of iPSCs and genome editing to functionally characterize human genetic variants associated with common disease.

   
Session Chair:

Cashell Jaquish, NHLBI, USA
10:10-10:30
The UK Human Induced Pluripotent Stem Cells Initiative (HIPSCI): Up date and application to metabolic disorders
Ludovic Vallier, University of Cambridge, United Kingdom
10:30-10:50
Directing iPSC to Specific Lineages
Mohan C. Vemuri, Termo Fisher Scientific, USA
10:50-11:10
Phenotypic Similarities Between iPSC derived endothelial cells and native pulmonary artery
Marlene Rabinowitch, Stanford University, USA
11:10-11:30
Generation of a cohort of human iPSC and iPSC-derived cardiomyocytes from 222 individuals to study the role of human variants in cardiac phenotypes
Kelly Frazer, University of California San Diego, USA
11:30-11:50
The Influence of Donor Age on Genetic and Epigenetic Characteristics of iPSCs
Kristin Baldwin, Scripps Research Institute, USA
11:50-12:10
Using iPSC-derived cardiomyocytes for biomarker and drug development
Ulrich Broeckel, Medical College Wisconsin, USA
12:10-12:30
iPSC-based modeling of blood-born disease: clinical trials in a test tube
George Murphy, Boston University, USA