Humanity in a Dish

Wednesday, 24 June, 08:30-12:30
Stockholmsässan Room A4

Organized by:
Chad A. Cowan
Harvard University, USA

Genome-wide association studies have identified many common genetic variants that influence human health and disease. In this focus session we will bring together experts in stem cell biology and human genomics to discuss recent progress and challenges in developing cell based functional genomic assays at scale for common diseases in cohort studies, as well as highlight iPSC resources available for genomic research.

There will be two sessions:
Session I: COREdinates: stem cell core facilities group

Highlighting the roles that core facilities play in cell therapies and disease modeling applications, including the production and banking of iPSC cohorts.

Session Chair:

Mark Tomishima, Memorial Sloan Kettering Cancer Center, USA
Overview of COREdinates and preclinical development work for Parkinson’s consortia
Mark Tomishima, Memorial Sloan Kettering Cancer Center, USA
Essential 8™ Medium: New Application Horizons for Culturing Human Pluripotent Stem Cells (hPSCs)
Roland Leathers, Termo Fisher Scientific, USA
Are all iPSC created equal? A comparison of iPSC from different source tissue
Jennifer Moore, RUCDR, USA
Taming the beast; 5S practice applied to large scale iPS production
Chris Kirton, Sanger Institute, United Kingdom
Realizing the Potential: Ensuring Accessibility of Cell Line and Data Resources
Tenneilee Ludwig, WiCell, USA

Session II: The functional annotation of human genetic variants

Highlighting ongoing efforts in several labs to use large cohorts of iPSCs and genome editing to functionally characterize human genetic variants associated with common disease.

Session Chair:

Cashell Jaquish, NHLBI, USA
The UK Human Induced Pluripotent Stem Cells Initiative (HIPSCI): Up date and application to metabolic disorders
Ludovic Vallier, University of Cambridge, United Kingdom
Directing iPSC to Specific Lineages
Mohan C. Vemuri, Termo Fisher Scientific, USA
Phenotypic Similarities Between iPSC derived endothelial cells and native pulmonary artery
Marlene Rabinowitch, Stanford University, USA
Generation of a cohort of human iPSC and iPSC-derived cardiomyocytes from 222 individuals to study the role of human variants in cardiac phenotypes
Kelly Frazer, University of California San Diego, USA
The Influence of Donor Age on Genetic and Epigenetic Characteristics of iPSCs
Kristin Baldwin, Scripps Research Institute, USA
Using iPSC-derived cardiomyocytes for biomarker and drug development
Ulrich Broeckel, Medical College Wisconsin, USA
iPSC-based modeling of blood-born disease: clinical trials in a test tube
George Murphy, Boston University, USA