Critical Challenges involved in making large scale human ipsc resources available to a global community

Wednesday, 24 June, 08:30-12:30

Organized by:
Michael Sheldon, PhD
RUCDR Biologics, Rutgers University, USA

Session I: Quality Control and Characterization

Data requirements for iPS cells that are accepted by repositories for distribution, identifying a set of characterization assays that should be performed, how best to deal with documenting genomic stability and pluripotency, and repository logistics (sample handling, storage and distribution).

"The Central Role of Biorepositories in the iPSC Field"

Michael Sheldon, RUCDR Infinite Biologics

"Genetic stability of human pluripotent stem cells"
Peter Andrews, International Stem Cell Initiative (ISCI)/Sheffield

"Procurement, banking, testing and supply of hPSCs for both research and clinical application: experiences of the UK Stem Cell Bank and a consensus from the International Stem Cell Banking Initiative"
Glyn Stacey, National Institute for Biological Standards and Control (NIBSC)

"The European Bank for induced pluripotent Stem Cells approach to cell line characterization"
Tim Allsopp, European Bank for induced pluripotent Stem Cells (EBISC)/Pfizer

"Standardized Reagents to Support iPS Cell Generation, Validation, and Banking"
Erik Hadley, Stem Cell Technologies

Session II: Informatics and Global Coordination

Harmonizing the various collections of hiPSCs around the world, working towards the creation of single (or centralized) portal(s) which allow us to search all of the iPS repositories worldwide for a particular line, improving public awareness of the existence of these collections and how they can be accessed. Additionally, the important issues of IP and regulatory hurdles to their dissemination, both to the academic and industrial communities, will be addressed.

"hESCreg: Pluripotent stem cell registries for data comprehension and comparison"

Andreas Kurtz, Human Embryonic Stem Cell Registry (hESCReg)

"Developing a single point of truth for iPSC information: An open- sourced, semantic web approach"
Richard Pearse, Eagle l

"Standards for iPSC data storage and distribution"
Ian Streeter, European Molecular Biology Laboratory - European Bioinformatics Institute

"IP and ethics considerations in stem cell distribution"
Emmanuelle Astoul, Wellcome Trust Sanger Institute

"Challenges and opportunities in resource and data integration: an NIH perspective"
David Panchision, National Institute of Mental Health (NIMH)