Schedule of Events (subject to change)

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Pre-Meeting Schedule
Tuesday, 23 June
Workshop on Clinical Translation (registration required)9:00-17:00
Karolinska Institutet
Huddinge Campus
Auditorium, Novum Building

Participants will gain a broad understanding of the translational pathway, including early phase trials and what to consider for the longer term in taking a stem-cell based product to market.
Wednesday, 24 June
Focus Sessions (no registration required)8:30-12:30
Stockholmsmässan


Industry Committee Focus Session: Biotechnology Entrepreneurialism-How Scientific Discoveries Translate into a Business Opportunity or So You Want to Spin out a Company!

Humanity in a Dish - Presented by Chad Cowan, Harvard University, USA

Critical Challenges Involved in Making Large Scale Human iPSC Resources Available to a Global Community -
Presented by Michael Sheldon, RUCDR Infinite Biologics, Rutgers University, USA


Meeting Schedule
Wednesday, 24 June, 2015
Plenary I — Presidential Symposium
Supported by Janssen Research & Development, LLC 13:00-15:15
Opening Remarks
President's Address:
Rudolph Jaenisch, Whitehead Institute for Biomedical Research and MIT, USA
Presentation of the 2015 McEwen Award for Innovation to Irving Weissmann and Hans Clevers  
Presentation of the 2015 ISSCR Public Service Award to Alan Trounson

Fred H. Gage, Salk Institute for Biological Sciences, USA
Jürgen Knoblich, IMBA – Institute of Molecular Biotechnology, Austria
Shinya Yamanaka, Center for iPS Cell Research & Application, Japan
Anne McLaren Memorial Lecture: Jeannie T. Lee, Massachusetts General Hospital and Harvard Medical School, USA
Refreshment Break 15:15-16:00 
EXHIBIT HALL OPEN 15:30-20:30
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Plenary II — Regeneration and Engraftment
Exhibit Hall Open 15:30-20:30 16:00-18:05 
Jonas Frisen, Karolinska Institutet, Sweden
Kari K. Alitalo, University of Helsinki, Finland
Elly Tanaka, DFG Research Center for Regenerative Therapies, Technische Universitaet Dresden, Germany
Poster Teasers 

Ernest McCulloch Memorial Lecture:Hiromitsu Nakauchi, University of Tokyo, Japan and Stanford University School of Medicine, USA
Reception & Poster Presentation 118:05-20:30
EXHIBIT HALL OPEN 15:30-20:30
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Thursday, 25 June, 2015
Morning Coffee8:15-9:00 
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Plenary III — Disease Modeling
Supported by Burroughs Wellcome Fund 9:00-11:20
Carla Kim, Boston Children's Hospital Stem Cell Program, USA
Hans Clevers, Hubrecht Institute, Netherlands
Poster Teasers
Nissim Benvenisty,
Hebrew Institute, Israel
Erika Sasaki, Advanced Research Center, Keio University, Central Institute for Experimental Animals, Japan
Steven A. Goldman, University of Copenhagen, Denmark and University of Rochester Medical Center, USA 

Lunch11:20-13:15
EXHIBIT HALL OPEN 11:00-20:00
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Innovation Showcases
Industry Presentations 11:30-12:30
Irvine Scientific
11:30-12:00
12:00-12:30
Fluidigm Corporation
11:30-12:00
12:00-12:30
Biological Industries
11:30-12:00
12:00-12:30
Lonza
11:30-12:00
12:00-12:30
Stemgent
11:30-12:00
12:00-12:30
Concurrent Session I
5 Tracks, each including 1 invited speaker, 4 abstract speakers, 3 poster teasers 13:15-15:10 
Click on each session track in the white bar to view the full list of speakers
  • Session IA:
    Neural Stem Cells
    and Differentiation


    Magdalena Götz
    ,
    Institute of Stem Cell Research, Helmholtz Zentrum
    Muenchen, Germany

    Supported by
    StemCells, Inc.

    Session IB:
    Hematopoiesis




    Hanna Mikkola
    ,
    University of California
    Los Angeles, USA
    Session IC:
    Control & Induction of Pluripotency



    Bing Lim
    ,
    Genome Institute of Singapore and Merck Research Lab, Singapore and Stanford University School of Medicine, USA
    Session ID:
    Single Cell Biology




    Fuchou Tang
    ,
    Peking Institute, China

    Supported by
    Fludigm

    Session IE:
    Germline and RNA
    Biology




    Haifin Lin
    ,
    Yale University School of Medicine
    USA
  • Concurrent IA: Neural Stem Cells and Differentiation
    Supported by: StemCells Inc.
    TOPIC OVERVIEW, Chair: Arturo Alvarez-Buylla, University of California San Francisco, USA

    MECHANISMS OF ENDOGENOUS AND FORCED NEURONAL REPAIR
    Magdalena Götz
    Institute of Stem Cell Research, Helmholtz Zentrum Muenchen, Germany


    NEW PLAYERS CONTROLLING RADIAL GLIAL CELLS COMMITMENT AND DIFFERENTIATION TO EPENDYMAL CELLS
    Stavros Taraviras
    Medical School, University of Patras, Greece 


    SPINAL CORD EPENDYMAL CELLS ARE FUNCTIONALLY HETEROGENEOUS WITH RESTRICTED PROGENITOR CELLS AND STEM CELLS
    Moa Stenudd
    Karolinska Institutet, Sweden

    ASCL1/MASH1 COORDINATELY REGULATES GENE EXPRESSION AND THE CHROMATIN LANDSCAPE DURING NEUROGENESIS
    Diogo S. Castro
    Instituto Gulbenkian de Ciencia, Portugal

    TRANSCRIPTOMIC CHARACTERIZATION OF SINGLE FIXED HUMAN RADIAL GLIAL PROGENITORS
    Boaz P. Levi
    Allen Institute for Brain Science, USA


    CONSECUTIVE BUILDING BLOCKS OF HUMAN NEURAL STEM CELL ONTOGENY DERIVED FROM PLURIPOTENT STEM CELLS: FUNDAMENTALS AND IMPLICATIONS
    Yechiel Elkabetz
    Tel-Aviv University, Israel 
  • Concurrent IB: Hematopoiesis
    TOPIC OVERVIEW, Chair: George Q. Daley, Boston Children's Hospital, USA

    TRANSCRIPTIONAL CONTROL OF HEMOGENIC ENDOTHELIUM FATE
    Hanna Mikkola
    University of California, Los Angeles, USA

    THE SEROTONERGIC NERVOUS SYSTEM REGULATES HEMATOPOIETIC STEM CELL PRODUCTION VIA THE HYPOTHALAMIC-PITUITARY-INTERRENAL AXIS
    Trista E. North
    Beth Israel Deaconess Medical Center, Harvard Medical School, USA

    EXTRA PHYSIOLOGIC OXYGEN SHOCK/STRESS (EPHOSS) BLUNTS HEMATOPOIETIC STEM CELL PHENOTYPE/FUNCTION VIA REACTIVE OXYGEN SPECIES AND THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE
    Heather Ann O'Leary
    Indiana University School of Medicine, USA

    REPROGRAMMING SHORT TERM BLOOD STEM CELLS TO A LONG TERM FATE BY PROSTAGLANDIN E2
    Eva M. Fast
    Harvard University, USA

    THE OPPOSING ROLES OF LET-7C AND MIR-125 IN HUMAN HEMATOPOIETIC STEM CELL MAINTENANCE AND PROLIFERATION
    Salemiz Sandoval
    University of California, Los Angeles, USA

    INTERFERON SIGNALING PROMOTES MATURATION OF AGM HSCS
    Peter Geon Kim
    Boston Children's Hospital, USA


  • Concurrent IC: Control and Induction of Pluripotency
    TOPIC OVERVIEW, Chair: Hongkui Deng, Peking University, China

    DIRECT REPROGRAMMING TO SOMATIC PROGENITOR CELLS: LINEAGE COMMITMENT REVISITED
    Bing Lim
    Genome Institute of Singapore and Merck Research Lab, Singapore and Stanford University School of Medicine, USA


    M6A RNA METHYLATION IS REGULATED BY MICRORNAS AND PROMOTES REPROGRAMMING TO PLURIPOTENCY
    Ying Zhang
    Institute of Zoology, Chinese Academy of Sciences, China

    LIN28 PHOSPHORYLATION COUPLES SIGNALING TO THE POST-TRANSCRIPTIONAL CONTROL OF PLURIPOTENCY
    Kaloyan M. Tsanov
    Harvard Medical School, USA

    KLF4 NUCLEAR EXPORT REQUIRES ERK ACTIVATION AND INITIATES EXIT FROM NAIVE PLURIPOTENCY
    Jennifer A. Mitchell
    University of Toronto, Canada

    UNCOVERING NOVEL MECHANISMS AND INDUCERS OF PLURIPOTENCY VIA COMBINATORIAL ANTIBODY SCREENING
    Joel W. Blanchard
    The Scripps Research Institute, USA

    A PRIMITIVE GROWTH FACTOR IS SUFFICIENT TO INDUCE STABLE NAÏVE STATE HUMAN PLURIPOTENCY VIA A LIF- AND FGF-INDEPENDENT PATHWAY; REPROGRAMMING IN THIS NOVEL GROWTH FACTOR CONFERS SUPERIOR DIFFERENTIATION
    Cynthia Bamdad
    Minerva Biotechnologies, USA


  • Concurrent ID: Single Cell Biology
    Supported by Fluidigm
    TOPIC OVERVIEW, Chair: Fred H. Gage, The Salk Institute, USA

    DISSECTING GENE REGULATION NETWORK IN HUMAN EARLY EMBRYOS AT SINGLE-CELL AND SINGLE-BASE RESOLUTION
    Fuchou Tang
    Peking University, China


    EARLY LINEAGE BIFURCATION DURING DIFFERENTIATION OF EMBRYONIC STEM CELLS REVEALED BY SINGLE-CELL TRANSCRIPTOMICS
    Stefan Semrau
    Whitehead Institute for Biomedical Research, United States

    EARLY B-CELL FACTOR 2 IDENTIFIES MESENCHYMAL STEM CELLS IN MOUSE SKIN TISSUE
    Lakshmi Sandhow
    Karolinska Institutet, Sweden

    DECODING THE REGULATORY NETWORK FOR BLOOD DEVELOPMENT FROM SINGLE-CELL GENE EXPRESSION MEASUREMENTS
    Victoria Moignard
    University of Cambridge, United Kingdom

    DEFECTS IN MYOGENIC TRANSDIFFERENTIATION REVEALED BY ALIGNMENT OF SINGLE-CELL PSEUDOTIME SERIES EXPERIMENTS
    Cole Trapnell
    University of Washington, USA

    SINGLE CELL RNA SEQUENCING UNCOVERS CLOSE RELATIONSHIP BETWEEN DOPAMINE AND SUBTHALAMIC NUCLEUS NEURON LINEAGES
    Nigel Kee
    Ludwig Institute for Cancer Research, Sweden



  • Concurrent IE: Germline and RNA Biology
    TOPIC OVERVIEW, Chair: Kathrin Plath, University of California, Los Angeles School of Medicine, USA

    UNITING MAJOR CONSTITUENTS OF THE GENOME: THE ROLE OF piRNAS IN THE GERMLINE
    Haifan Lin
    Yale University School of Medicine, USA


    LNCRNA DEANR1 REGULATES HUMAN ENDODERM DIFFERENTIATION BY FACILITATING FOXA2 ACTIVATION
    Wei Jiang
    Boston Children's Hospital, USA

    REARRANGEMENT OF CARBOXYLCYTOSINE PATTERNS INITIATES GENOME REPROGRAMMING DURING SPERMIOGENESIS
    Alexey Ruzov
    University of Nottingham, United Kingdom


    PIWIL3 AND piRNAS IN MAMMALIAN OOCYTES
    Bernard A. Roelen
    Utrecht University, Netherlands

    GENETIC DISSECTION OF M6A RNA METHYLATION FUNCTION AND ROLE IN EARLY MAMMALIAN DEVELOPMENT
    Shay Geula
    Weizmann Institute of Science, Israel

    IDENTIFICATION OF TRANSLATIONAL NETWORKS ORCHESTRATING PLURIPOTENT CELL FATE THROUGH EIF4E REGULATION
    Henia Darr
    Ichan School of Medicine at Mount Sinai, USA



Refreshment Break15:10-16:00 
EXHIBIT HALL OPEN 11:00-20:00
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Concurrent Session II
5 Tracks, each including 1 invited speaker, 4 abstract speakers, 3 poster teasers16:00-17:55 
Click on each session track in the white bar to view the full list of speakers
  • Session IIA:
    Disease Modeling




    Hideyuki Okano
    ,
    Keio University School
    of Medicine, Japan
    Session IIB:
    Stem Cell Regulatory Networks and Models



    Joanna Wysocka
    ,
    Stanford University
    USA

    Supported by 
    Stemgent, part of the ReproCELL Group

    Session IIC:
    Lineage Relationships and Clonality



    Thomas Zwaka
    ,
    Icahn School of Medicine
    at Mount Sinai, USA
    Session IID:
    Stem Cells in Model Organisms



    David Traver
    ,
    University of California,
    San Diego, USA
    Session IIE:
    Cell Adhesion, Motility and Migration


    Anna-Katerina Hadjantonakis
    ,
    Sloan-Kettering Institute for Cancer Research, USA
  • Concurrent IIA: Disease Modeling
    TOPIC OVERVIEW, Chair: David Scadden, Massachusetts General Hospital and Harvard Stem Cell Institute, USA

    MODELING OF HUMAN NEUROLOGICAL / PSYCHIATRIC DISORDERS USING IPSC TECHNOLOGY AND TRANSGENIC NON-HUMAN PRIMATES

    Hideyuki Okano
    Keio University, School of Medicine, Japan

    MOLECULAR AND FUNCTIONAL DEFICIENCIES IN FRAGILE X NEURONS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
    Dalit Ben-Yosef
    Tel-Aviv Sourasky Medical Center & Tel-Aviv University, Israel

    UNBIASED INTERROGATION OF POLYGENIC BRAIN DISORDERS USING STEM CELL MODELS
    Lindy Barrett
    Broad Institute, USA

    DRUG SCREENING ON HUTCHINSON GILFORD PROGERIA USING PLURIPOTENT STEM CELLS REVEALS NEW PHARMACOLOGICAL MODULATORS OF PRELAMIN A FARNESYLATION
    Xavier Nissan
    CECS I-Stem, France

    MODELING GATA4 HAPLOINSUFFICIENCY USING IPS-DERIVED CARDIOMYOCYTES REVEALS GENOME-WIDE INTERACTION WITH TBX5 AND HISTONE MODIFIERS NECESSARY FOR CARDIAC LINEAGE COMMITMENT AND FUNCTION
    Yen-Sin Ang
    Gladstone Institutes and University of California, USA

    CONNECTING GENOTYPE TO DISEASE PHENOTYPE: DISSECTING THE EFFECT OF PARKINSON’S DISEASE ASSOCIATED RISK VARIANTS ON GENE EXPRESSION
    Frank Soldner
    Whitehead Institute for Biomedical Research, USA




  • Concurrent IIB: Stem Cell Regulatory Networks and Models
    Supported by Stemgent, part of the ReproCELL Group
    TOPIC OVERVIEW, Chair: Austin G. Smith, Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, UK

    ON PECULIARITIES OF BEING A HUMAN: USING STEM CELLS TO STUDY HUMAN EVOLUTION AND HUMAN-SPECIFIC ASPECTS OF DEVELOPMENTAL GENE REGULATION
    Joanna Wysocka
    Stanford University School of Medicine, USA 

    COUPLING PIONEER FACTORS AND SUPER-ENHANCERS TO GOVERN STEM CELL PLASTICITY AND LINEAGE CHOICE
    Rene Christian Adam
    The Rockefeller University, USA

    PLATYPUS INDUCED PLURIPOTENT STEM CELLS REVEAL THAT ACQUISITION OF SOX2 RESPONSIVENESS FACILITATED EXPANSION OF THE PLURIPOTENCY NETWORK DURING MAMMALIAN EVOLUTION
    Deanne J. Whitworth
    University of Queensland, Australia

    IDENTIFICATION OF REGULATORY NETWORKS IN HSCS AND THEIR IMMEDIATE PROGENY VIA INTEGRATED PROTEOME, TRANSCRIPTOME, AND DNA METHYLOME ANALYSIS
    Daniel Klimmeck
    German Cancer Research Center (DKFZ), Germany

    MITOTIC INHERITANCE OF THE PLURIPOTENCY NETWORK ACTIVITY
    Pablo Navarro
    Institut Pasteur, France


    THE CURIOUS CASE OF TROPHOBLAST DIFFERENTIATION FROM HUMAN PLURIPOTENT STEM CELLS
    Micha Drukker
    Helmholtz Center Munich, Germany


  • Concurrent IIC: Lineage Relationships and Clonality
    TOPIC OVERVIEW, Chair: Sean Morrison, Children's Research Institute at UT Southwestern, USA

    CELL COMPETITION IN PLURIPOTENT STEM CELLS
    Thomas P. Zwaka
    Icahn School of Medicine at Mount Sinai, USA

    CHARACTERIZATION AND THERAPEUTIC MODULATION OF A DERMAL LINEAGE WITH INTRINSIC FIBROGENIC POTENTIAL
    Graham G. Walmsley
    Stanford University School of Medicine, USA

    INDUCTION OF ROD PHOTORECEPTOR-SPECIFIC PROGENITORS FROM ADULT MOUSE RETINAL STEM CELLS
    Brian G. Ballios
    University of Toronto, Canada

    GENETIC LINEAGE TRACING DEMONSTRATES MULTIPOTENCY OF PREMIGRATORY AND MIGRATORY NEURAL CREST CELLS IN VIVO
    Arianna Baggiolini
    University of Zurich, Switzerland

    A QUANTITATIVE FRAMEWORK FOR INTERROGATING LINEAGE POTENTIAL VIA GENETIC TAGGING IN HIGHLY COMPLEX CELL POPULATIONS
    Chee Jia Chin
    University of California, Los Angeles, USA

    THE HUMAN DEFINITIVE HEMOGENIC ENDOTHELIUM GENERATING MULTIPOTENT HEMATOPOIETIC PROGENITORS REPRESENTS A DISTINCT LINEAGE FROM ARTERIAL VASCULAR ENDOTHELIUM
    Andrea Ditadi
    McEwen Centre for Regenerative Medicine, Canada


  • Concurrent IID: Stem Cells in Model Organisms
    TOPIC OVERVIEW, Chair: Leonard I. Zon, Boston Children's Hospital, USA

    DECODING THE MOLECULAR CUES THAT REGULATE HSC SPECIFICATION
    David Traver
    University of California, San Diego, USA

    NEW NICHE AND NOVEL STEM CELL DURING DEVELOPMENT OF DROSOPHILA MUSCULATURE
    Rajesh Dattaram Gunage
    The National Centre for Biological Sciences – Tata Institute of Fundamental Research, India


    MESENCHYMAL INDUCED CELL DEATH AND EPITHELIAL PHAGOCYTOSIS REGULATE THE HAIR FOLLICLE STEM CELL POOL
    Valentina Greco
    Yale Medical School, USA

    YORKIE MEDIATES A SIZE SENSING MECHANISM DURING PLANARIAN REGENERATION
    Alexander Lin
    University of Toronto, Canada

    THE CALCINEURIN CONTROLS PROPORTIONAL GROWTH OF ZEBRAFISH REGENERATING FINS
    Christopher Antos
    DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Germany

    MAMMALIAN ARF SUPPRESSES VERTEBRATE EPIMORPHIC REGENERATION
    Robert Hesse
    University of California San Francisco, USA


  • Concurrent IIE: Cell Adhesion, Motility and Migration
    TOPIC OVERVIEW, Chair: Elly Tanaka, DFG Research Center for Regenerative Therapies, Technische Universitaet Dresden, Germany

    GUTS AND GASTRULATION: LIVE IMAGING CELL DYNAMICS TO INTERROGATE MORPHOGENESIS IN THE EARLY MAMMALIAN EMBRYO
    Anna-Katerina Hadjantonakis
    Sloan-Kettering Institute for Cancer Research, USA

    SPECIFIC INHIBITION OF HEMATOPOIETIC CELL MIGRATION TO ADIPOGENIC MARROW - “NO PLACE TO HOME”
    Troy C. Lund
    University of Minnesota, USA

    CHONDROITIN SULFATE BLOCKS NEURAL STEM CELL ENTRANCE INTO A BRAIN INJURY SITE THROUGH THE NOGO RECEPTOR AND RHOA/ROCK ACTIVATION
    Layla Testa Galindo
    Federal University of São Paulo, Brazil

    RAPID ASSESSMENT OF DIRECTED MIGRATION: A NOVEL MICROFLUIDIC-BASED 3D POTENCY TEST FOR COMBINATORIAL SCREENING OF STEM CELLS (SC).
    Enrique A. Ros
    Universidad de los Andes, Chile

    TRANSCRIPTOME ANALYSIS OF THE AVIAN PRIMITIVE STREAK REVEALS NOVEL MARKERS INVOLVED IN MESENDODERM DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
    Cantas Alev
    RIKEN Center for Developmental Biology, Japan

    SILICA BIOREPLICATION PROVIDES NEW INSIGHTS INTO THREE-DIMENSIONAL STEM CELL SPHEROIDS
    Riina Harjumäki
    University of Helsinki, Finland


Friday, 26 June, 2015
Morning Coffee8:15-9:00 /div>
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Plenary IV — Pluripotency and Mechanisms of Reprogramming9:00-11:20
ISSCR Business Meeting
Konrad Hochedlinger, Howard Hughes Medical Institute and Harvard Medical School, USA
Amanda G. Fisher, Imperial College London, United Kingdom
Poster Teasers
Austin G. Smith, Wellcome Trust – Medical Research Council Stem Cell Institute, University of Cambridge, United Kingdom
Duanqing Pei, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, China

Lunch11:20-13:15 
EXHIBIT HALL OPEN 11:00-20:00
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Innovation Showcases
Industry Presentations 11:30-12:30
Life Technologies
11:30-12:00
12:00-12:30
STEMCELL
Technologies
11:30-12:00
12:00-12:30
Corning
11:30-12:00
12:00-12:30
Ajinomoto
11:30-12:00
12:00-12:30
Bio-Techne
11:30-12:00
12:00-12:30
Concurrent Session III
5 Tracks, each including 1 invited speaker, 4 abstract speakers, 3 poster teasers13:15-15:10 
Click on each session track in the white bar to view the full list of speakers
  • Session IIIA:
    Neural Degeneration




    Kevin Eggan
    ,
    Harvard University,
    USA
    Session IIIB:
    Stem Cells and Cancer




    Yashuhiro Yamada
    ,
    Center for iPS Cell Research & Application, Kyoto University,
    Japan
    Session IIIC:
    Transdifferentiation
    and Reprogramming




    Thomas Graf
    ,
    Center for Genomic
    Regulation, Spain
    Session IIID:
    Pancreas, Lung, Liver, Intestine



    Henrik Semb
    ,
    Copenhagen University,
    Denmark

    Supported by Novo Nordisk Foundation
    Session IIIE:
    Epithelial and Mesenchymal
    Stem Cells




    Shahin Rafii
    ,
    Weill Cornell Medical College,
    USA

    Supported by GE Healthcare
  • Concurrent IIIA: Neural Degeneration
    TOPIC OVERVIEW, Chair: Sally Temple, Neural Stem Cell Institute, USA

    NEW IDEAS ABOUT ALS FROM STUDIES OF STEM CELL-DERIVED MOTOR

    Kevin C. Eggan
    Harvard University, USA

    IPSC-DERIVED NEURONS WITH PS1 DE9 MUTATIONS HAVE REDUCED TRANSCYTOSIS DUE TO CALCIUM DYSREGULATION
    Sol M. Reyna
    University of California, San Diego, USA

    THE LOSS OF C9ORF72 PROTEIN FUNCTION CAUSES THE DEGENERATION OF ALS PATIENT-DERIVED MOTOR NEURONS
    Justin K. Ichida
    University of Southern California, USA

    ENGRAFTABLE MUSCLE STEM CELLS ARE GENERATED FROM HUMAN IPS CELLS WITHOUT MYOGENIC TRANSGENE INDUCTION
    Hidetoshi Sakurai
    Center for iPS Cell Research & Application (CiRA), Kyoto University, Japan

    ELEVATED OLEIC ACID LEVELS WITHIN THE FOREBRAIN STEM CELL NICHE SUPPRESS NEURAL STEM CELL ACTIVATION IN ALZHEIMER’S DISEASE
    Laura K. Hamilton
    Université de Montreal, Canada

    THE AMYLOID CASCADE IN IPSC-DERIVED HUMAN CORTICAL NEURONS
    Jacqueline P. Robbins
    King's College London, United Kingdom


  • Concurrent IIIB: Stem Cells and Cancer
    TOPIC OVERVIEW, Chair: Amy Wagers, Harvard University, USA

    CANCER CELL REPROGRAMMING UNVEILS STABLE MAINTENANCE OF CANCER CELL IDENTITY THROUGH KEY ONCOGENIC SIGNALS
    Yasuhiro Yamada
    Center for iPS Cell Research & Application, Kyoto University, Japan


    REACTIVATION OF MULTIPOTENCY BY ONCOGENIC PIK3CA INDUCES BREAST TUMOR HETEROGENEITY
    Alexandra Van Keymeulen
    Université Libre de Bruxelles (ULB), Belgium

    SOX9 AS A DOWN-STREAM TARGET IN RAS/MEK-DRIVEN PEDIATRIC GLIOMA
    Hanna Sabelström
    University of California, San Francisco, USA

    THE EPIGENETIC MODIFIER EZH2 CONTROLS MELANOMA METASTASIS THROUGH SILENCING OF TUMOR SUPPRESSIVE METABOLIC NETWORKS.
    Daniel Zingg
    University of Zurich, Switzerland

    TARGETED REVERSAL OF INFLAMMATORY CYTOKINE DRIVEN ADAR1 LET-7 FAMILY EDITING IN CANCER STEM CELLS
    Maria Anna Zipeto
    University of California San Diego, USA

    INTERFERENCE WITH STEM CELL-SPECIFIC SURVEILLANCE MECHANISMS RESULTS IN SKIN TUMOUR INITIATION
    Catherin Niemann
    University of Cologne, Germany

  • Concurrent IIIC: Transdifferentiation and Reprogramming
    TOPIC OVERVIEW, Chair: Timothy Allsopp, Neusentis Regenerative Medicine, UK

    C/EBP ALPHA CREATES AN ELITE CELL STATE IN B CELLS
    Thomas Graf
    Center for Genomic Regulation, Spain


    SOX2-INDUCED CONVERSION OF NG2 GLIA INTO NEURONS IN THE ADULT CEREBRAL CORTEX FOLLOWING ACUTE INVASIVE INJURY
    Christophe Heinrich
    Grenoble Institute of Neurosciences-Inserm U 836, France

    HIGH-RESOLUTION MAPPING OF REPROGRAMMING EPIGENETICS FOLLOWING IDENTIFICATION OF MBD3/NURD COMPONENT GATAD2A AS A KEY TARGET FOR ACHIEVING DETERMINISTIC PLURIPOTENCY INDUCTION
    Yoach Rais
    Weizmann Institute of Science, Israel

    PLURIPOTENCY FACTOR-INDUCED LINEAGE CONVERSION INVOLVES A TRANSIENT PASSAGE THROUGH AN IPS CELL STAGE
    Ori Bar-Nur
    Harvard University, USA

    UNRAVELLING THE DYNAMICS OF REPROGRAMMING OF FIBROBLASTS INTO NEURONS
    Qian Yi Lee
    Stanford University, USA

    IDENTIFICATION OF A POTENT SIGNALLING PATHWAY THAT ORCHESTRATES BOTH REPROGRAMMING AND TRANSDIFFERENTIATION.
    Tyson Joel Ruetz
    Centre for Regenerative Medicine, University of Edinburgh, United Kingdom

  • Concurrent IIID: Pancreas, Liver Lung, Intestine
    Supported by: Novo Nordisk Foundation
    TOPIC OVERVIEW, Chair: Christine L. Mummery, Leiden University Medical Center, Netherlands

    HOW TO MAKE BETA CELLS FOR CELL THERAPY IN DIABETES 
    Henrik Semb
    Danish Stem Cell Center, Denmark

    IDENTIFICATION OF AN ENDODERM-DERIVED KDR+ PROGENITOR WITH A BI-POTENT LIVER AND ENDOTHELIAL FATE
    Valerie Gouon-Evans
    Icahn School of Medicine at Mount Sinai, USA

    GENOME EDITING IN HUMAN PLURIPOTENT STEM CELLS REVEALS DISTINCT AND OVERLAPPING ROLES OF GATA6 AND GATA4 IN HUMAN ENDODERM AND PANCREAS DEVELOPMENT
    Zhong-Dong Shi
    Sloan Kettering Institute, USA

    MODELING HUMAN BRANCHING MORPHOGENESIS USING HUMAN EMBRYONIC STEM CELLS IN VIVO
    Ya-Wen Chen
    Columbia University, USA

    DEFINING THE ROLE OF MULE IN INTESTINAL CANCER
    Carmen Dominguez-Brauer
    Ontario Cancer Institute, Canada

    HUMAN PLURIPOTENT STEM CELL MODELING OF AIRWAY EPITHELIAL DIFFERENTIATION
    Katherine A. Benson
    Boston University School of Medicine, USA
  • Concurrent IIIE: Epithelial and Mesenchymal Stem Cells
    Supported by GE Healthcare
    TOPIC OVERVIEW, Chair: Andras Simon, Karolinska Institutet, Sweden

    PLURIPOTENT-INDEPENDENT REGENERATION OF STABLE ORGANS ENABLED BY VASCULAR NICHE INDUCTION
    Shahin Rafii
    Weill Cornell Medical College, USA

    P53 CONTROLS AIRWAY EPITHELIAL PROGENITOR CELL SELF-RENEWAL AND DIFFERENTIATION
    Alicia M. Farin
    Cedars-Sinai Medical Center, USA

    A MOLECULAR CLASSIFICATION OF MESENCHYMAL STEM CELLS
    Christine Anne Wells
    The University of Queensland, Australia

    ROLES FOR MACROPHAGES IN WOUND-INDUCED HAIR FOLLICLE NEOGENESIS.
    Denise Gay
    INSERM UMR 967, France

    CELL-SHEET BASED STEM CELL THERAPY FOR OCULAR SURFACE
    Hiroaki Sugiyama
    Tokyo Women's Medical University, Japan

    FDA-APPROVED PHASE I CLINICAL TRIAL INVESTIGATING INTRATHECAL MESENCHYMAL STEM CELL-DERIVED NEURAL PROGENITORS (MSC-NP) IN MULTIPLE SCLEROSIS: AN INTERIM ANALYSIS
    Violaine K. Harris
    Tisch MS Research Center of New York, USA
Refreshment Break15:10-16:00
EXHIBIT HALL OPEN 11:00-20:00
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Plenary V — Therapy with Stem Cells 16:00-17:55
Supported by BOEHRINGER INGELHEIM
Stephen Huhn, StemCells, Inc., USA
Douglas A. Melton
, Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, USA
Patient Advocate Address: Marcus Storch, Stockholm, Sweden
Allan J. Robins, ViaCyte, Inc., USA
Katarina Le Blanc, Karolinska Institutet, Sweden
Poster Presentation III/Reception18:00-20:00 
EXHIBIT HALL OPEN 11:00-20:00
Saturday, 27 June, 2015
Morning Coffee8:15-9:00 
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Plenary VI — Immunology and Stem Cells 9:00-11:20
Supported by MESOBLAST

Carl H. June, University of Pennsylvania School of Medicine, USA
Patrick Aubourg, Hôpital Bicêtre, France
Juan Carlos Zúñiga-Pflücker, University of Toronto, Canada
John Ioannidis, Stanford University School of Medicine, USA
Presentation of the Outstanding Young Investigator Award supported by BD Biosciences
  OYIA Lecture: Paul J. Tesar, Case Western Reserve University, USA

Lunch11:20-13:15 
EXHIBIT HALL OPEN 11:00-15:30
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Innovation Showcases
Industry Presentations 12:00-12:30
BD Biociences
12:00-12:30
Miltenyi Biotech Gmb
12:00-12:30
Union Biometrica, Inc.
12:00-12:30
Merck Millipore
12:00-12:30
Merck Millipore
12:00-12:30
Concurrent Session IV
5 Tracks, each including 1 invited speaker, 4 abstract speakers, 3 poster teasers13:15-15:10 
Click on each session track in the white bar to view the full list of speakers
  • Session IVA:
    Road to the Clinic




    Robin Ali
    ,
    University College,
    London, UK
    Session IVB:
    Epigenetics




    Karen Adelman
    ,
    National Institute of Environmental Health Sciences,
    USA
    Session IVC:
    Modeling Disease with
    iPSCs




    Chad Cowan
    ,
    Harvard Stem Cell and Regenerative Biology, Harvard University,
    USA
    Session IVD:
    Tissue Engineering, Organ Development and Regeneration


    Christopher Chen
    ,
    Boston University and Harvard University, USA                 
    Session IVE:
    Stem Cells Niche



    Cristina Lo Celso
    ,
    Imperial College,
    London, UK
  • Concurrent IVA: Road to the Clinic
    TOPIC OVERVIEW, Chair: Deepak Srivastava, Gladstone Institutes, USA

    RETINAL REPAIR THROUGH TRANSPLANTATION OF PHOTORECEPTORS

    Robin Ali

    University College London, UK

    FIRST US PHASE I CLINICAL TRIAL OF GLOBIN GENE TRANSFER FOR THE TREATMENT OF BETA-THALASSEMIA MAJOR
    Farid Boulad
    Memorial Sloan Kettering Cancer Center, USA

    MITOCHONDRIAL COMPETITION AFTER NUCLEAR TRANSFER IN HUMAN OOCYTES
    Mitsutoshi Yamada
    The New York Stem Cell Foundation Research Institute, USA

    THE MORAL RESPONSIBILITIES OF ACADEMIC RESEARCH INSTITUTIONS TO SAFEGUARD THE INTEGRITY OF RESEARCH
    Zubin Master
    Albany Medical College, USA

    COMBINED TREATMENT OF SELF-ASSEMBLING PEPTIDES AND NEURAL PRECURSOR CELLS AFTER EXPERIMENTAL CERVICAL SPINAL CORD INJURY
    Klaus Zweckberger
    Department of Neurosurgery, Universtiy of Heidelberg, Germany

    SIMULTANEOUS REPROGRAMMING AND GENE CORRECTION OF PATIENT FIBROBLASTS
    Sara Emily Howden
    Murdoch Children's Research Institute, Australia


  • Concurrent IVB: Epigenetics
    TOPIC OVERVIEW, Chair: Haifan Lin, Yale University School of Medicine, USA

    PAUSING OF RNA POLYMERASE II REGULATES MAMMALIAN DEVELOPMENTAL POTENTIAL THROUGH CONTROL OF SIGNALING NETWORKS
    Karen Adelman

    National Institute of Environmental Health Sciences, USA

    COMPARATIVE EPIGENOMIC ANALYSIS OF REGULATORY ELEMENTS IN HUMAN AND CHIMPANZEE STEM CELLS
    Iñigo Narvaiza
    The Salk Institute for Biological Studies, USA

    STABLE X CHROMOSOME REACTIVATION IN FEMALE HUMAN INDUCED PLURIPOTENT STEM CELLS
    Tahsin Stefan Barakat
    University of Edinburgh, MRC Centre for Regenerative Medicine, United Kingdom

    SIGNALING COUPLES HAIR FOLLICLE STEM CELL QUIESCENCE WITH CHROMATIN STATES ASSOCIATED WITH PLASTICITY
    Tudorita Tumbar
    Cornell University, USA

    A NOVEL DNA METHYLATION REPORTER FOR REAL TIME TRACING OF EPIGENETIC CHANGES DURING DEVELOPMENT AND REPROGRAMMING, AT SINGLE CELL RESOLUTION
    Yonatan Stelzer
    Whitehead Institute for Biomedical Research, USA

    REGULATION OF MAMMALIAN DNA METHYLATION BY TRANSCRIPTION FACTOR BINDING
    Juliane Schmidt
    Friedrich Miescher Institute for Biomedical Research, Switzerland


  • Concurrent IVC: Modeling Disease with iPSCs
    TOPIC OVERVIEW, Chair: Nissim Benvenisty, Hebrew University, Israel

    ELUCIDATING METABOLIC DISEASE MECHANISMS USING HUMAN PLURIPOTENT STEM CELLS
    Chad Cowan

    Harvard Stem cell and Regenerative Biology, Harvard University, USA

    PATIENT-SPECIFIC IPSC DERIVED ENDOTHELIAL CELLS UNCOVER MECHANISMS RELATED TO PENETRANCE OF A BMPR2 MUTATION IN CAUSING PULMONARY ARTERIAL HYPERTENSION
    Mingxia Gu
    Stanford School of Medicine, USA

    ENHANCED CHONDROGENESIS OF INDUCED PLURIPOTENT STEM CELLS FROM PATIENTS WITH NEONATAL-ONSET MULTISYSTEM INFLAMMATORY DISEASE OCCURS VIA THE CASPASE 1-INDEPENDENT CAMP/PKA/CREB PATHWAY
    Junya Toguchida
    Institute for Frontier Medical Sciences, Kyoto University, Japan

    OPTICAL ACTION POTENTIAL RECORDING: A TOOL FOR CARDIAC DISEASE MODELING AND HIGH-THROUGHPUT DRUG SCREENING IN HIPSC-DERIVED CARDIOMYOCYTES
    Zhifen Chen
    Technical University of Munich, Germany

    THERAPEUTIC STRATEGIES THAT TARGET GENETIC RISK FOR PSYCHIATRIC DISORDERS
    Josh Chenoweth
    Lieber Institute for Brain Development, USA

    INDUCED PLURIPOTENT STEM CELL (IPSC) MODELING REVEALS A ROLE FOR GROWTH DIFFERENTIATION FACTORS (GDFS) IN THE ETIOLOGY OF β-THALASSEMIA
    Kim Vanuytsel
    Boston University School of Medicine, USA

  • Concurrent IVD: Tissue Engineering; Organ Development and Regeneration
    TOPIC OVERVIEW, Chair: Thomas Perlmann, Karolinska Institutet, Sweden

    FORCES, FORM, AND ENGINEERING CELL AND TISSUE FUNCTION
    Christopher S. Chen

    Boston University and Harvard University, USA

    REGENERATION OF THE ADULT ZEBRAFISH BRAIN: THE ROLE OF LINEAGE CONVERSION
    Michael Brand
    TU Dresden, BIOTEC/CRTD, Germany

    FUNCTIONAL SYSTEMS ANALYSIS OF THE ADULT MUSCLE STEM CELL IDENTIFIES CRUCIAL REGULATORS OF MUSCLE REGENERATION
    Johnny Kim
    Max Planck Institute for Heart and Lung Research, Germany

    MODELING HUMAN NEURAL TUBE ANATOMY THROUGH CULTURING OF STEM CELLS UNDER MICROFLUIDIC GRADIENTS
    Agnete Kirkeby
    Lund University, Sweden

    IMPAIRMENT IN FRACTURE HEALING IN A MOUSE MODEL OF TYPE 2 DIABETES IS DRIVEN BY SKELETAL STEM CELL NICHE DYSREGULATION
    Ruth Tevlin
    Stanford University, USA

    HUMAN EMBRYONIC STEM CELL DERIVED NEURAL CREST CELLS FOR PERIPHERAL NERVE REPAIR.
    Iwan Jones
    Umeå University, Sweden

  • Concurrent IVE: Stem Cell Niche
    TOPIC OVERVIEW, Chair: Hans C. Clevers, Hubrecht Institute, Netherlands


    PLASTIC INTERACTIONS BETWEEN NORMAL AND MALIGNANT HAEMATOPOIETIC CELLS AND THEIR BONE MARROW NICHES
    Cristina Lo Celso
    Imperial College London, UK

    WNT5A EXPRESSED BY THE NICHE IS REQUIRED TO MAINTAIN MIGRATORY PROPERTIES OF HEMATOPOIETIC STEM CELLS THROUGH THE PLANAR CELL POLARITY PATHWAY
    Christina Schreck
    Klinikum rechts der Isar der Technical University Munich, Germany

    COLONIZATION OF A HEMATOPOIETIC STEM CELL NICHE REVEALED BY LIGHTSHEET LIVE IMAGING OF THE ZEBRAFISH KIDNEY MARROW
    Owen J. Tamplin
    Boston Children's Hospital, USA

    DEEP IMAGING OF BONE MARROW SHOWS NON-DIVIDING HEMATOPOIETIC STEM CELLS ARE PERISINUSOIDAL
    Melih Acar
    UT Southwestern Medical Center, USA

    FUNCTIONAL SCREEN IDENTIFIES NOVEL REGULATORS OF MURINE HEMATOPOIETIC STEM CELL ENGRAFTMENT
    Shannon L. McKinney-Freeman
    St. Jude Children's Research Hospital, USA

    MICROENVIRONMENTAL REMODELING AS A PARAMETER AND PROGNOSTIC FACTOR OF HETEROGENEOUS LEUKEMOGENESIS IN ACUTE MYELOID LEUKEMIA
    Il-Hoan Oh
    Catholic University of Korea, Medical School, Korea

Refreshment Break14:50-15:40
EXHIBIT HALL OPEN 11:00-15:30
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Plenary VII — Making Tissues and Organs 16:00-18:20
  President-Elect Address: Sean J. Morrison, UT Southwestern Medical Center, USA

Deepak Srivastava, Gladstone Institutes, USA
Amy Wagers, Joslin Diabetes Center, Harvard University, USA
Masayo Takahashi, RIKEN Center for Developmental Biology, Japan
Closing Keynote: Robert Langer, Massachusetts Institute of Technology, USA
Closing Remarks
: Rudolph Jaenisch, Whitehead Institute for Biomedical Research and MIT, USA

SCHEDULE AT A GLANCE


Attendees are encouraged to include Wednesday morning sessions in their plans. Any registered attendee may attend the sessions.
Gage - PhotoDr. Gage studies the adult central nervous system and unexpected plasticity and adaptability to environmental stimulation. He models human neurological and psychiatric disease in vitro using human stem cells and studies the genomic mosaicism that exists in the brain as a result of mobile elements that are active during neurogenesis.
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knoblich photoThe Knoblich lab uses Drosophila and mouse genetics to identify the molecular mechanisms that control asymmetric cell division and the balance between proliferation and differentiation in neural stem cell lineages.
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Lee photo Dr. Lee specializes in the study of epigenetic regulation by long noncoding RNAs using X-chromosome inactivation as a model system.
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Frisen photoA main interest of Jonas Frisén’s research group is cellular plasticity in the central nervous system, in both the healthy and pathological situation.
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Nakauchi photoGoals of Dr. Nakauchi's work are to clarify the mechanism of stem cell self-renewal and to contribute to the cell/gene therapy and regenerative medicine.
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Clevers Hans portret 20-3-12Since 2012 Hans Clevers is President of the Royal Netherlands Academy of Arts and Sciences (KNAW). He is the recipient of multiple awards and Chevalier de la Legion d'Honneur (2005) and Knight in the Order of the Netherlands Lion (2012).
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Benvenisty_Photo1Prof. Benvenisty’s research projects focus on stem cell biology, tissue engineering, human genetics, and cancer research. He published numerous original and review papers on human pluripotent stem cells, and serves on the editorial board of various stem cell related journals.
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SasakiCurrently, her research group is attempting to understand the differences between rodent and primate stem cells and to establish methods of generating target-gene knockout and knock-in marmosets.
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Goetz photoThe Götz lab works on identifying key mechanisms regulating lineage progression from undifferentiated neural stem cells to committed neuronal or glial precursors in comparison to the programs activated in glial cells reacting to injury.
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Lim photoThe Lim team contributed significant discoveries about the genetic regulatory circuits in ES cells and genetic factors that impact on iPS reprogramming efficiency and quality. More recently they identified cancer stem cells in different cancers and their transcriptional signature that revealed novel classes of potential therapeutic targets.
Tang Fuchou Photo Our lab focuses on the epigenetic mechanisms of self-renewal and pluripotency of mouse embryonic stem cells, embryonic germ cells and Epi-Stem cells. Through this, we want to understand the epigenetic regulation of mammalian early embryonic development and the global epigenetic reprogramming during the development of primordial germ cells.
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Lin Haifan6_4_08cropDr. Lin has made key contributions to the demonstration of stem cell asymmetric division, the proof of the stem cell niche theory, the discovery of the Argonuate/PIWI gene family and their function in stem cell self-renewal and germline development, as well as the discovery of novel non-coding small RNAs called PIWI-interacting RNAs (piRNAs).
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Dr. Okano has been conducting basic research in the field of neural stem cells and iPS cells, spinal cord repair, and RNA binding proteins. Currently, his aim is to establish and characterize patients-specific iPS cells and transgenic non-human primate models for neuroscience research and neurological/psychiatric disorders.
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Traver photoThe Traver laboratory studies the formation and function of hematopoietic stem cells in the early embryo, and how the progeny of these cells provide immunity to the developing animal.
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Hadjantonakis2The overarching theme of her research is to decipher mechanisms underlying cell lineage specification and tissue morphogenesis. Quantitative analyses, often involving imaging at single-cell resolution, are a hallmark of the approach Kat and her collaborators take.
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Hochedlinger photo_1The Hochedlinger lab studies the molecular basis of stem cell self-renewal, differentiation and cellular reprogramming using embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and tissue stem cells as model systems.
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Smith Austin 2014Professor Smith’s expertise is in the field of stem cell biology and he has pioneered key advances in the field of Embryonic Stem (ES) Cell research. His research focuses on the molecular and cellular controls of embryonic and somatic stem cells, and on interconversion between pluripotent and tissue-restricted states.
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Pei Duanqing photoPei lab continues to explore new ways to improve iPS technology, dissect the reprogramming mechanisms driven by Oct4/Sox2/Klf4 or fewer factors, and employ iPSCs to model human diseases in vitro.
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Yamada_PhotoOur laboratory is interested in cancer epigenetics. Especially, we employ iPSC technology for actively manipulating epigenetic regulations in both cancer cells and somatic cells, aiming to understand the role of epigenetic regulation in the development and maintenance of cancer cells.
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Semb photoDr. Semb’s research group is focused on understanding how cell polarity and tissue architecture control cell fate specification. They also work to translate this knowledge into efficient and reliable strategies for regenerative medicine in diabetes.
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Melton Doug photo 2Dr. Melton’s laboratory studies how cell differentiation is directed during development and the role of stem cells in tissue regeneration. Their primary focus is the study of genes and cells that make pancreatic tissue with the goal being to make pancreatic cells for transplantation into people with diabetes.
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damour pixKevin D’Amour, Ph.D. is an expert in stem cell science, an inventor of ViaCyte’s key patents and a co-author of high profile publications in renowned scientific journals
leBlanc photoDr. LeBlanc's main research interest is mesenchymal stem cells, haematopoietic stem cell transplantation and immunology.
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Tesar photo OYIA 010milnerPaul Tesar’s graduate and postdoctoral studies culminated in a landmark paper in Nature where he described the isolation of a new type of pluripotent stem cell termed epiblast stem cells. Paul joined the CWRU School of Medicine faculty in 2010 and his laboratory has continued to develop cutting edge stem cell technologies for better understanding and treatment of nervous system disorders including multiple sclerosis, pediatric leukodystrophies, and brain cancer.
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June photoDr. June studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection.
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Zuniga-Pflucker photoJuan Carlos Zúñiga-Pflücker
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Ali photo DSC_0114 The main focus of Dr. Ali’s research is the development of gene and cell therapy for the treatment of retinal disorders. He established the world’s first clinical trial of gene therapy for retinopathy. His group has also provided the first proof-of-concept for effective transplantation of photoreceptors.
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Cowan photoOur goal is to understand how naturally occurring human genetic variation protects (or predisposes) some people to cardiovascular and metabolic disease—the leading cause of death in the world—and to use that information to develop therapies that can protect the entire population from disease.
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Lo_Celso,_Cristina_cropped_HighResDr. Lo Celso’s research focuses on the cellular mechanisms regulating haematopoietic stem cell function and leukaemia development and uses an interdisciplinary approach combining continuous development of mouse bone marrow intravital microscopy techniques, computational analysis, molecular profiling and interventions and mathematical modelling.
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Srivastava 031512LGDr. Srivastava’s laboratory discovered the genetic basis for cardiac septal and valve defects which revealed complex regulation of progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. They use this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes.
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Takahashi photoMasayo Takahashi discovered the potential of stem cells as a tool for retinal therapy. She is a team leader of the retinal regeneration research team and her clinical specialty is retinal disease – macular diseases and retinal hereditary diseases in particular.
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Langer 2 x 2.5 colorOur work is at the interface of biotechnology and materials science. A major focus is the study and development of polymers to deliver drugs, particularly genetically engineered proteins, DNA and RNAi, continuously at controlled rates for prolonged periods of time.
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