Integrating Viral Vectors, Gene Transfer into Hematopoietic Stem Cells and Therapies in Human Monogenic Diseases
David Williams, Boston Children's Hospital, USA
Phase I/II Clinical Trial of Hematopoietic Stem Cell Gene Therapy for the Treatment of Metachromatic Leukodystrophy
Alessandra Biffi, Ospedale San Raffaele, Italy
Transdifferentiation and Its Implementation in Autologous Cell Replacement Therapy for Diabetes
Sarah Ferber Sheba Medical Center and Tel-Aviv University, Israel
Ethical Issues in Cell- and Gene-Based Research and Therapy
Nancy King, Wake Forest University, USA
Regenerating the Heart of a Non-human Primate
Charles Murry, University of Washington, USA
Five Poster Teasers
A Hematopoietic
Stem Cells CHAIR OVERVIEW
Amy Wagers
Joslin Diabetes Center, USA Corey Cutler
Dana-Farber Cancer Institute, USA | B Epigenetics of
Stem Cells CHAIR OVERVIEW
Kathrin Plath University of California, Los Angeles School of Medicine, USA
Michaela Frye
Wellcome Trust, Centre for Stem Cell Research, UK | C Stem Cell
Therapies CHAIR OVERVIEW
Deepak Srivastava
Gladstone Institute of Cardiovascular Disease, USA Nicholas Boulis
The Emory Clinic, USA | D Chemical Control
of Stem Cell Behavior CHAIR OVERVIEW
Hongkui Deng
Peking University, China Stephen Minger
GE Healthcare, UK | E Germ Cell Biology
and Artifical Gametes CHAIR OVERVIEW
Thomas Graf
Center for Genomic Regulation, Spain Jinsong Li
Institute of Biochemistry & Cell Biology SIBS CAS, China Josef Martin Penninger
Institute of Molecular Biotechnology (IMBA), Austria |
Concurrent IIIA – Hematopoietic Stem Cells
INVITED SPEAKER
Prostaglandin-Modulated Umbilical Cord Blood Hematopoietic Stem Cell Transplantation
Corey Cutler, Dana-Farber Cancer Institute, USA
Notchless at the Crossroad Between Ribosome Biogenesis and Adult Hematopoietic Stem Cell Maintenance
Michel Cohen-Tannoudji, Institut Pasteur, France
Nuclear Translocation of GATA3 Negatively Regulates Self-Renewal in Activated Long-term Hematopoietic Stem Cells
Catherine Frelin, Ontario Cancer Institute, Canada
The Intrinsic Apoptosis Caspase Cascade Regulates Hematopoietic Stem Cell Homeostasis and Function
Michael J. White, The Walter and Eliza Hall Institute of Medical Research, Australia
POSTER BRIEFS (THREE MINUTES EACH)
New Insights into Hematopoietic Stem and Progenitor Cell Lineage Contributions and Kinetics Via Clonal Barcoding in a Non-Human Primate Model
Brian Li, National Heart, Lung, and Blood Institute, USA
miR-126 Controls Hematopoietic Stem Cell Function
Francesco E. Boccalatte, Telethon Institute for Gene Therapy, Italy
Omics Landscape of Hematopoietic Stem Cells and Multipotent Progenitors
Nina Cabezas-Wallscheid, German Cancer Research Center, Germany
Human Definitive and Primitive Hematopoiesis are Specified Simultaneously from Human Pluripotent Stem Cells
Christopher M. Sturgeon, McEwen Centre for Regenerative Medicine, Canada
Concurrent IIIB – Epigenetics of Stem Cells
INVITED SPEAKER
Cytosine-5 Methylation in Normal Tissues and Diseases
Michaela Frye, Wellcome Trust Centre for Stem Cell Research, UK
DNA Methyltransferase-3 Dependent Non Random Segregation of DNA Strands in Differentiating Embryonic Stem Cells
Christian Elabd, University of California, Berkeley, USA
During Reprogramming, Aid Stabilizes a Stem Cell Phenotype by Removing Epigenetic Memory of Secondary Pluripotency Genes
Ritu Kumar, Weill Cornell Medical College, USA
Comparative and Spatiotemporal Epigenomic Annotation of Regulatory DNA
Shu Xiao, University of Melbourne, Australia
POSTER BRIEFS (THREE MINUTES EACH)
Dynamics of X-chromosome Inactivation in Human Embryos and Newly Derived Human Pluripotent Stem Cells
Shila Mekhoubad, Harvard University, USA
Genome Organizer SATB1 Regulates Differentiation-Associated Silencing of the Nanog Locus by Modulating its Nuclear Positioning in Human Embryonic Stem Cells
Vladimir A. Botchkarev, University of Bradford/Boston University, USA
RNF12 is Essential for X Inactivation in Female Mouse Embryonic Stem Cells and is Required for Female Mouse Development
Tahsin Stefan Barakat, Erasmus Medical College, University Medical Center Rotterdam, Netherlands
Identification of Sister Chromatids in Cells using DNA Template Strands
Peter Lansdorp, European Institute for the Biology of Ageing, Netherlands
Concurrent IIIC – Stem Cell Therapies
INVITED SPEAKER
Surgical Approaches to Human Spinal Cord Stem Cell Transplantation in Amyotrophic Lateral Sclerosis
Nicholas Boulis, The Emory Clinic, USA
Human iPSC-derived Oligodendrocyte Progenitor Cells Can Efficiently and Completely Restore Central Myelin in Animal Models of Both Congenital and Acquired Demyelination
Martha S. Windrem, University of Rochester, USA
Autologous Point of Care Bone Marrow Concentrate (BMC) for the Treatment of Lumbar Degenerative Disc Disease: IRB Controlled Prospective Study
Matthew Pouliot, The Orthopedic Stem Cell Institute, USA
Ought Patients to Pay to Participate in Cell Transfer Clinical Trials?
Jason S. Robert, Arizona State University, USA
POSTER BRIEFS (THREE MINUTES EACH)
Reversible Cell Immortalization Allows HAC-mediated Gene Correction of Human Dystrophic Myogenic Progenitors
Francesco Saverio Tedesco, University College London, UK
The Effectiveness of Allogeneic Mesenchymal Stromal Cells of Bone Marrow in Patients with Refractory Crohn's Disease
Oleg Knyazev, Central Research Institute of Gastroenterology, Russia
Human Induced Pluripotent Stem Cells Differentiate Into Pure Populations of Endothelial Cells Mediated by Set Similar Protein Through VE-cadherin Transcriptional Activation
Andriana Margariti, Queen's University Belfast, UK
Exploiting Artificial Nucleases for Targeted Transgene Integration in Human Hematopoietic Stem Cells and Induced Pluripotent Stem Cells Derived from Normal Donors and SCID-X1 Patients
Angelo Lombardo, San Raffaele Scientific Institute, Italy
Concurrent IIID – Chemical Control of Stem Cell Behavior
INVITED SPEAKER
Innovating Preclinical Drug Development & Human Cell Therapy
Stephen Minger, GE Healthcare, UK
High-throughput Screening Identifies a Novel Oleate Synthesis Inhibitor that Selectively Eliminates Human Pluripotent Stem Cells and Prevents Teratoma Formation
Uri Ben-David, Hebrew University Stem Cell Unit, Israel
Identification of Small Molecules for Maturation of iPS-derived Hepatocyte-like Cells
Jing Shan, Massachusetts Institute of Technology, USA
Development of High-content Imaging Assay to Evaluate Differentiation Towards Functional Brown Adipose Tissue in Adipose and Skeletal Muscle Progenitors
Lauren Drowley, AstraZeneca, Sweden
POSTER BRIEFS (THREE MINUTES EACH)
Control the Behavior of Intestinal Stem Cells
Xiaolei Yin, Koch Institute, Massachusetts Institute of Technology, USA
Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Targeted Mesoderm and Endoderm Cell Fates
Albert Q. Lam, Brigham and Women's Hospital, USA
Poster Brief TBD
Combinatorial Small Molecule Modulation of hESC-derived Pancreatic Multipotent Progenitor Cells
Quinn P. Peterson, Harvard University, USA
Concurrent IIIE – Germ Cell Biology and Artificial Gametes
INVITED SPEAKER #1
Generation of Mammalian Haploid Embryonic Stem Cells
Jinsong Li, Institute of Biochemistry and Cell Biology SIBS CAS, China
Rebuilding Pluripotency from Mouse Primordial Germ Cells
Harry G. Leitch, Wellcome Trust/MRC Stem Cell Institute, UK
The TC2-mTORC1 Signaling Axis Controls Germline Stem Cell Fate
Robin M. Hobbs, Australian Regenerative Medicine Institute, Monash University, Australia
Identification and Pluripotency of Mouse Spermatogonial Stem Cells
Hossein Azizi, University of Heidelberg, Germany
POSTER BRIEF (THREE MINUTES)
Exogenous SUpplementation with Activin A Boosts Germ Cell Directed Differentiation of Human Embryonic Stem Cells
Galbha Duggal, Ghent University Hospital, Belgium
INVITED SPEAKER #2
Yeast Genetics in Mammalian Stem Cells
Josef Penninger, Institute of Molecular Biotechnology, Austria
A Stem Cells in Organ Development CHAIR OVERVIEW
Leonard Zon
Boston Children's Hospital, USA Henrik Semb
Danish Stem Cell Center, Denmark | B Self Renewal Mechanisms CHAIR OVERVIEW
Arturo Alvarez-Buylla
University of California San Francisco, USA Rongwen Xi
National Institute of Biological Sciences, China | C Immunology and Stem Cells CHAIR OVERVIEW
Irving Weissman
Stanford University School of Medicine, USA Ashleigh Boyd
Boston University, USA | D Stem Cells and Cancer CHAIR OVERVIEW
Connie Eaves
BC Cancer Research Centre, Canada Mina Bissell
Lawrence Berkeley National Laboratory, USA | E Chromatin Regulation in Stem Cells CHAIR OVERVIEW
Derek van der Kooy
University of Toronto, Canada Jay Bradner
Dana-Farber Cancer Institute, USA |
Concurrent IVA – Stem Cells in Organ Development
INVITED SPEAKER
Shape is Fate
Henrik Semb, University of Copenhagen, Denmark
Pax2 Maintains the Nephron Lineage by Repressing Stromal Cell Fates in Nephron Progenitor Cells During Mammalian Kidney Development
Akio Kobayashi, Harvard Medical School, USA
miR-142-3P Unlocks the Hemangioblast Program in the Mesodermal Precursors of Hematopoietic Stem Cells and the Major Vessels
Rachael Nimmo, UCL Cancer Institute, UK
Developmental Segregation of Bone Marrow HSC Niche Formation from Endochondral Ossification by Specialized Neural Crest- and Mesoderm-derived MSCs, Respectively
Joan Isern, Spanish National Cardiovascular Center (CNIC), Spain
POSTER BRIEFS (THREE MINUTES EACH)
Heart Field Origin of Great Vessel Precursors Relies on Nkx2.5-mediated Vasculogenesis
Noelle Paffett-Lugassy, Massachusetts General Hospital, USA
Prostaglandin E2 Regulates Cell Fate Decisions and Organ Growth During Liver and Pancreas Development
Sahar Nissim, Brigham and Women's Hospital, USA
Poster Brief TBD
VEGFR2/KDR/FLK-1 Marks a Novel, Functional, and Conserved Liver Progenitor Cell
Valerie Gouon-Evans, Mount Sinai School of Medicine, USA
Concurrent IVB – Self Renewal Mechanisms
INVITED SPEAKER
Dynamic Ineractions Between Stem Cells and their Microenvironment During Intestinal Homeostasis and Regeneration in Drosophila
Rongwen Xi, National Institute of Biological Sciences, China
Transcriptional Regulation Mediated by the DNA Repair Complex XPC-RAD23B-CETN2 in Embryonic Stem Cells
Claudia Cattoglio, University of California at Berkeley, USA
The THO Complex Regulates Pluripotency Gene mRNA Export and Maintains ESC Self-renewal
Guang Hu, National Institute of Environmental Health Sciences, USA
The Mechanism Underlying Epidermal Tissue Self-renewal by the RNA Degrading Exosome Complex
Devendra S. Mistry, University of California, San Diego, USA
POSTER BRIEFS (THREE MINUTES EACH)
HMGA2 Expression is Required for the High Self-Renewal Activity of Fetal Hematopoietic Stem Cells
Michael R. Copley, BC Cancer Agency, Canada
MUC1* Ligand, NM23, is a Novel Growth Factor that Reverts Unmodified Human Stem Cells to the Naïve State in a bFGF-free, Feeder-free Defined System
Cynthia C. Bamdad, Minerva Biotechnologies, USA
Runx1 Controls a Reversible Transitory State Between Stem and Progenitor Cells in Mouse Hair Follicle that is at the Origin of Skin Tumors
Tudorita Tumbar, Cornell University, USA
The Rate of Protein Translation Regulates Hematopoietic Stem Cell Self-Renewal
Robert A. J. Signer, University of Texas Southwestern Medical Center, USA
Concurrent IVC – Immunology and Stem Cells
INVITED SPEAKER
Assessing the Immune Response to Transplantation of Pluripotent Stem Cell Derivatives
Ashleigh S. Boyd, Boston University School of Medicine, USA
Directed Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitors
Audrey Parent, University of California, San Francisco, USA
Induced Tolerance to Embryonic Stem Cell Transplantation by Host Conditioning with Total Lymphoid Irradiation, Antithymocyte Serum and Regulatory T Cell
Yuqiong Pan, Stanford University, USA
Blockade of Costimulatory Molecule Signaling Promotes Survival of Human Embryonic Stem Cell-derived Endothelial Cells by Inducing T Cell Immunoglobulin 3 Upregulation and Improves Cardiac Function
Julia D. Ransohoff, Stanford School of Medicine, USA
POSTER BRIEFS (THREE MINUTES EACH)
Bone Cells Govern T Lymphopoiesis by Regulating Thymic Emigrants from Bone Marrow
Vionnie W. C. Yu, Harvard Stem Cell Institute, USA
Host Macrophages are a Barrier to the Engraftment of Embryonic Stem Cell-Derived Hematopoietic Progenitors
Heather L. Thompson, University of California, Merced, USA
Mesenchymal Stem Cells Stimulate an Immune Response by Providing Immune Cells with Toll-like Receptor 2 Ligand
Ada Weinstock, Weizmann Institute of Science, Israel
Human iPS Cell-derived Antigen-targeted T Lymphocytes Eradicate CD19-positive Tumor Cells
Maria Themeli, Memorial Sloan-Kettering Cancer Center, USA
Concurrent IVD – Stem Cells and Cancer
INVITED SPEAKER
Examining the "Cancer Stem Cell" Hypothesis as it Relates to Breast Cancer
Mina J. Bissell, EOL Berkeley National Lab, USA
A Chromatin Factor Screen in Zebrafish Identifies Neural Crest Regulator SATB2 as a Novel Driver of Melanoma
Ellen van Rooijen, Boston Children's Hospital, USA
BMP2 Determines Luminal Switch and Promotes Related Breast Tumors through the Disruption of the FOXC1/FOXA1 Balance
Marion Chapellier, CRCL-U1052-UMR5286, Lyon, France
Targeting Cancer Stem Cells in Medulloblastoma is NEcessary but not Sufficient for Tumour Control
Tzvi Aviv, Hospital for Sick Children, Canada
POSTER BRIEFS (THREE MINUTES EACH)
BCL11A: a Novel Breast Cancer Gene Which PLays a Critical Role in Mammary Stem Cells and Suppresses P53
Walid Khaled, Wellcome Trust Sanger Institute, UK
E2F1 is Critical for Survival of Chronic Myeloid Leukaemia (CML) Stem Cells
Francesca Pellicano, University of Glasgow, UK
Implicating the Pluripotency Factor Lin28 in Kidney Development and Wilms Tumor
Achia Urbach, Boston Children's Hospital, USA
Overexpression of the EMT Regulator ZEB2/SIP1 Results in a Block in T Cell Development and Identifies this Gene as a New Driver for T Cell Lymphoblastic Leukemia
Jody Haigh, University of Ghent, Belgium
Concurrent IVE – Chromatin Regulation in Stem Cells
INVITED SPEAKER
Chemical Control of Gene Expression
Jay Bradner, Dana Farber Cancer Institute, USA
A Functional Map of Nuclear Proteolysis
Andre Catic, Massachusetts General Hospital, USA
A Library of Endogenously Tagged Fluorescent Proteins in Embryonic Stem Cells Reveals a Linker Histone Chaperone Involved in Pluripotency and Differentiation
Eran Meshorer, The Hebrew University of Jerusalem, Israel
Histone Variant H2A.X-mediated Epigenetic Mechanisms are Critical for Maintaining Genome Stability and Pluripotency in ES and iPS Cells
Andrew Xiao, Yale Stem Cell Center, USA
POSTER BRIEFS (THREE MINUTES EACH)
A Dedicated Role for Transcription Factor CDX2 in Intestinal Stem Cell Functions
Adrianna K. San Roman, Harvard University, USA
Enhancer Transcribed RNAs in Embryonic Stem Cells are Regulated by the TET Family of Proteins
Sridhar Rao, BloodCenter of Wisconsin, USA
Prediction of Chromatin State Variability
Luca Pinello, Dana-Farber Cancer Institute, USA
Oct4 Switches Partnering from Sox2 to Sox17 to Reinterpret the Enhancer Code and Specify Endoderm
Lawrence W. Stanton, Genome Institute of Singapore, Singapore