Program Highlights

Monday, 27 February

Opening Keynote Session
13:00-14:00

WELCOME REMARKS: Nancy Witty, ISSCR CEO and Timm Schroeder, Basel Stem Cell Network

KEYNOTE: Magdalena Götz, Helmholtz Zentrum München, Germany

NEURONAL REPLACEMENT AFTER INJURY - TURNING GLIA INTO NEURONS

Modeling Tissue Development 
14:00-15:00

CHAIR: Timm Schroeder, Swiss Federal Institute of Technology (ETH) Zürich, Switzerland

14:00-14:30: Fiona Doetsch, University of Basel, Biozentrum, Switzerland
REGULATION OF STEM CELLS IN THE ADULT MAMMALIAN BRAIN

14:30-14:45: Evangelos Kiskinis, Northwestern University Feinberg School of Medicine, U.S. 
DISSECTING DNA METHYLATION DYNAMICS DURING THE DEVELOPMENT AND FUNCTION OF THE HUMAN SPINAL CORD

14:45-15:00: Ernest Arenas, Karolinska Institutet, Sweden
MOLECULAR MODELING AT A SINGLE CELL LEVEL OF HUMAN MIDBRAIN DOPAMINERGIC NEURON DEVELOPMENT IN VIVO AND IN STEM CELLS

Coffee Break - 15:00-15:30

Modeling Tissue Development 
15:30-16:45

CHAIR: Timm Schroeder, Swiss Federal Institute of Technology (ETH) Zürich, Switzerland

15:30-16:00: Darrell Kotton, Boston University, USA
ENDODERMAL DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO UNDERSTAND DEVELOPMENT AND REGENERATE IN VIVO ORGAN FUNCTION

16:00-16:15: Nicole Dubois, Mount Sinai Hospital, U.S.
FOXA2 MARKS A VENTRICULAR PROGENITOR POPULATION DURING HEART DEVELOPMENT

16:15-16:45: Olivier Pourquié, Harvard University/Brigham and Women's Hospital, U.S.
MAKING SKELETAL MUSCLE IN VITRO TO STUDY MUSCULAR DYSTROPHIES

Welcome Reception
16:45-18:15

Tuesday, 28 February

Cellular Disease Models I
09:00-10:30

CHAIR: Martin Pera, University of Melbourne, Australia

9:00-9:30: Caleb Webber, University of Oxford, United Kingdom
STEM CELL MODELS FOR NEURODEGENERATIVE DISEASES: NEW THERAPEUTICS, SINGLE CELL APPROACHES AND CAVEATS

9:30- 9:45: Sovan Sarkar, University of Birmingham, United Kingdom
THERAPEUTIC MODULATION OF AUTOPHAGY IN HUMAN INDUCED PLURIPOTENT STEM CELL-BASED MODEL OF A NEURODEGENERATIVE LIPID STORAGE DISORDER

9:45- 10:00: Jerome Mertens, The Salk Institute for Biological Studies, U.S.
AGE-EQUIVALENT INDUCED NEURONS AND REJUVENATED IPSC-DERIVED NEURONS TO STUDY SPORADIC ALZHEIMER’S DISEASE IN THE CONTEXT OF HUMAN AGING

10:00- 10:15: Annie Kathuria, King's College London, United Kingdom
IPSC DERIVED HYPOTHALAMIC NEURONS FROM AUTISTIC INDIVIDUALS SHOW MORPHOGENETIC ABNORMALITIES DURING EARLY DEVELOPMENT

10:15-10:30: An Verheyen, Janssen Pharmaceutica NV, Belgium
MODELING FTDP-17 LINKED TAUOPATHIES AND ALZHEIMER’S DISEASE WITH GENETICALLY MODIFIED HUMAN IPSC

Coffee Break - 10:30-11:00

Cellular Disease Models I
11:00-12:00

CHAIR: Martin Pera, University of Melbourne, Australia

11:00-11:30: Anja Nitzche, Pfizer, United Kingdom
MODELLING THE PHARMACOLOGICAL AND CLINICAL RESPONSE IN PRIMARY ERYTHROMELALGIA USING INDUCED PLURIPOTENT STEM CELLS

11:30- 11:45:  Filip Roudnicky, F. Hoffmann-La Roche Ltd, Switzerland
MODELING OF SEVERE METABOLIC GENETIC DISEASES IN VITRO USING GENOME EDITING AND HUMAN PLURIPOTENT STEM CELL DIFFERENTIATION TO VASCULAR ENDOTHELIAL CELLS

11:45-12:00: Nicola Beer, University of Oxford, United Kingdom
INTERROGATING THE FULL SLC30A8 ALLELIC SPECTRUM IN HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED ISLET-LIKE CELLS

Poster Session I and Lunch - 12:00-14:30 (Odd numbered posters presented)

Emerging Technologies
14:30-16:00

CHAIR: Nissim Benvenisty, Hebrew University, Israel

14:30-15:00: Matthias Lutolf, École Polytechnique Fédérale de Lausanne, Switzerland
ENGINEERING IN VITRO ORGANOGENESIS

15:00-15:15: Andrew Cohen, Drexel University, U.S.
CELLPHONES TO SUPERCOMPUTERS: HARDWARE AND SOFTWARE FOR INTEGRATED ANALYSIS AND VISUALIZATION OF 5-D MICROSCOPY MOVIES OF PROLIFERATING CELLS

15:15-15:30: Daniel Coutu, Swiss Federal Institute of Technology (ETH) Zürich, Switzerland
QUANTITATIVE MULTIDIMENSIONAL TISSUE CYTOMETRY OF MURINE BONE AND MARROW STEM CELLS

15:30-16:00: Colin Akerman, University of Oxford, United Kingdom
INTEGRATING OPTOGENETIC TECHNOLOGIES INTO HUMAN INDUCED PLURIPOTENT STEM CELL RESEARCH

Coffee Break - 16:00-16:30

Drug Discovery I  
16:30-17:30

CHAIR: Mark Burcin, F. Hoffmann-La Roche Ltd, Basel, Switzerland

16:30-17:00: Martin Pera, University of Melbourne, Australia
INHIBITION OF DYRK1A DISRUPTS NEURAL LINEAGE SPECIFICATION IN HUMAN PLURIPOTENT STEM CELLS

17:00-17:30: Kevin Eggan, Harvard University, U.S.
PITFALLS AND PROMISE OF USING HUMAN STEM CELL FOR STUDYING DISEASE

Reception - 17:30-18:30

Wednesday, 1 March

Cellular Disease Models II
09:00-10:30

CHAIR: Olivier Pourquié, Harvard University/Brigham and Women's Hospital, U.S.

9:00-9:30: Danwei Huangfu, Memorial Sloan Kettering Cancer Center, U.S.
HUMAN PANCREAS DEVELOPMENT AND DISEASE THROUGH THE LENS OF PLURIPOTENT STEM CELLS

9:30- 9:45: Daniel Tornero, Lund University, Sweden
RECONSTRUCTION OF A FUNCTIONAL THALAMO-CORTICAL PATHWAY IN STROKE-INJURED RAT BRAIN USING HUMAN SKIN-DERIVED CELLS

9:45- 10:00: Stefania Fedele, University of Basel, Switzerland
IN VITRO MODELING OF GLUCOCEREBROSIDASE (GBA) FUNCTION IN PARKINSON´S DISEASE

10:00- 10:30: Ludovic Vallier, Cambridge Stem Cell Institute and Wellcome Trust Sanger Institute, United Kingdom
STEM CELLS TO MODEL AND TO STUDY LIVER DISEASES

Coffee Break - 10:30-11:00

Cellular Disease Models II
11:00-12:00

CHAIR: Olivier Pourquié, Harvard University/Brigham and Women's Hospital, U.S.

11:00-11:30: Pura Muñoz-Cánoves, ICREA, Pompeu Fabra University and CNIC, Spain
ROLE OF PROTEOSTASIS IN STEMNESS

11:30- 11:45: Carlo Cusulin, F. Hoffmann-La Roche Ltd, Switzerland
THE ROLE OF Aβ IN INDUCING AN ALZHEIMER’S DISEASE SPECIFIC TRANSCRIPTIONAL PROFILE IN IPSC-DERIVED NEURONS

11:45-12:00: Agnes Maillet, A*STAR, Singapore
ANALYZING THE FUNCTIONAL IMPACT OF GENETIC VARIANTS ON DOXORUBICIN-INDUCED CARDIOTOXICITY USING GENOME EDITING TECHNOLOGY

Poster Session II and Lunch - 12:00-14:30 (Even numbered posters presented)

Drug Discovery II 
14:30-15:45

CHAIR: Melissa K. Thomas, Eli Lilly and Co., U.S.

14:30-15:00: Martin Graf, F. Hoffmann-La Roche Ltd, Innovation Center Basel, Basel, Switzerland
HUMAN STEM CELLS MODELS FOR DRUG DISCOVERY

15:00-15:15: Brent Ryan, University of Oxford, United Kingdom
ESTABLISHING PHENOTYPIC SCREENING ASSAYS IN IPSC-DERIVED DOPAMINERGIC NEURONS FROM PARKINSON’S DISEASE PATIENTS

15:15-15:45: Viktor Lakics, AbbVie Deutschland GmBH and Co. KG, Germany
INTRA- AND INTER-LABORATORY REPRODUCIBILITY OF A CELLULAR DISEASE PHENOTYPE AND A LONG-TERM DIFFERENTIATION PROTOCOL FOR HUMAN IPSC-DERIVED NEURONS: A MULTI-SITE, MULTI-OMICS STUDY

Closing Keynote Session
15:45-16:30

KEYNOTE: Lorenz Studer, Memorial Sloan Kettering Cancer Center, U.S.

CLOSING REMARKS: Jack Price, StemBANCC

Registration Desk and Badge Pickup Hours

The registration desk is located at the Congress Center Basel, Hall 4 Building, Second Floor Foyer:
Monday, 27 February 10:00 – 18:15
Tuesday, 28 February 8:00 – 18:30
Wednesday, 1 March 8:00 –16:30

      Co-Hosted by:

Venue

Congress Center Basel
Messepl. 21 
Basel, Switzerland 4058