Conference Program

WEDNESDAY, OCTOBER 24

8:15 a.m.

Registration

9:00 – 9:15 a.m.

Welcome/Opening Remarks 

Deepak Srivastava, MD
Director, Roddenberry Stem Cell Center at Gladstone
Shinya Yamanaka, MD, PhD
President, International Society for Stem Cell Research
R. Sanders Williams, MD
President, Gladstone Institutes
Rod Roddenberry
Founder, Roddenberry Foundation

Reprogramming to Pluripotency

9:15 – 9:55 a.m.

Chair: Robert Blelloch, MD, PhD
University of Caifornia, San Francisco

Induction of Pluripotency by Defined Factors

Shinya Yamanaka, MD, PhD
Gladstone Institute of Cardiovascular Disease and UCSF Director, Center for iPS Research and Application, Kyoto University

9:55 – 10:35 a.m.

Embryonic Stem Cells: Capture of a Ground State

Austin Smith, PhD
Wellcome Trust Centre for Stem Cell Research
University of Cambridge

10:35 – 10:55 a.m.

Break

10:55 – 11:35 a.m.

Defining Mechanisms of Reprogramming 

Kathrin Plath, Ph.D.
University of California, Los Angeles School of Medicine

11:35 a.m. – 12:15 p.m.

12:15 – 12:30 p.m.

Resistance to Nuclear Reprogramming by Eggs and Oocytes

John Gurdon, Kt, DPhil, DSc, FRS
The Wellcome Trust/Cancer Research UK Gurdon Institute
University of Cambridge

Special Presentation
Deepak Srivastava and Nancy Witty

12:30 – 1:30 p.m.

Lunch

1:30 – 2:10 p.m.

Chair: Yadong Huang, MD, PhD
Gladstone Institute of Neurological Disease and UCSF

Direct Reprogramming of Fibroblasts to Cardiomyocyte-like Cells

Deepak Srivastava, MD
Gladstone Institute of Cardiovascular Disease and UCSF

Direct Lineage Reprogramming to Generate Neuronal Cell Types

Marius Wernig, MD, PhD
Institute for Stem Cell Biology and Regenerative Medicine
Stanford University School of Medicine 

2:50 – 3:10 p.m.

Break

3:10 – 3:50 p.m.

A Chemical Approach to Reprogramming

Sheng Ding, PhD
Gladstone Institute of Cardiovascular Disease and UCSF

3:50 – 4:30 p.m.

Direct Reprogramming of Human Fibroblasts

Mick Bhatia, PhD
McMaster Stem Cell and Cancer Research Institute

4:30  – 4:45 p.m.

Modeling Smooth Muscle Vascular Disease by Direct Reprogramming of Patient-Specific Dermal Fibroblasts

Kimberly Cordes, PhD
Gladstone Institute of Cardiovascular Disease
Roddenberry Fellow

4:45 – 6:30 p.m.

Poster Session and Wine & Cheese Reception
Gladstone Institutes Lobby

THURSDAY, OCTOBER 25

8:15 a.m.

9:00 – 9:05 a.m.


9:05 – 9:10 a.m.

Registration

Welcome
Deepak Srivastava, MD

Remarks
The Honorable Edwin M. Lee
Mayor of San Francisco

SESSION III

Epigenetics in Cell Programming and Reprogramming

9:10 – 9:50 a.m.

Chair: Melanie Ott, MD, PhD
Gladstone Institute of Virology and Immunology and UCSF

Control of Gene Expression Programs

Richard A. Young, PhD
Whitehead Institute
Massachusetts Institute of Technology

9:50 –10:30 a.m.

Epigenetic Landscape During Cardiac Differentiation

Benoit Bruneau, PhD
Gladstone Institute of Cardiovascular Disease and UCSF

10:30 –10:50 a.m.

Break

10:50 – 11:30 a.m.

Chair: John Dimos, PhD
iPierian Inc.

Directed Differentiation of Human Pluripotent Stem Cells -- From Pain to Therapeutic Gain

Lorenz Studer, MD
Memorial Sloan-Kettering Cancer Center

11:30 a.m. – 12:10 p.m.

Novel Mechanisms of Reprogramming Elucidated by Heterokaryons

Helen Blau, PhD
Stanford Institute for Stem Cell Biology and Regenerative Medicine

12:10 – 12:25 p.m.

iPSCs as a Model for Human Germ Line and Embryo Development

Renee Reijo-Pera,PhD
Stanford Institute for Stem Cell Biology and Regenerative Medicine

12:25 – 1:30 p.m.

Lunch

1:30 – 2:30 p.m.

Moderator: Bruce R. Conklin, MD
Gladstone Institute of Cardiovascular Disease and UCSF

Challenges and Opportunities in Cellular Reprogramming

Arnold Kriegstein, MD, PhD
University of California San Francisco

Mahendra S. Rao, MD, PhD
National Institutes of Health Center for Regenerative Medicine

Beth Seidenberg, MD
Kleiner Perkins Caufield & Byers

Irving Weissman, MD
Institute for Stem Cell Biology and Regenerative Medicine
Stanford University School of Medicine

Shinya Yamanaka, MD, PhD
Gladstone Institute of Cardiovascular Disease and UCSF Director, Center for iPS Research and Application, Kyoto University

Applications of Reprogramming Technology 

2:30 – 3:10 p.m.

Chair: Natalie Dewitt, PhD
California Institute for Regenerative Medicine

Directed Cell Fate Reprogramming of Mouse Fibroblasts to Hepatocyte-Like Cells

Atsushi Suzuki, PhD
Kyushu University, Fukuoka, Japan

3:10 – 3:30 p.m.

Break

3:30 – 4:10 p.m.

Patient-derived iPSCs as Tools to Study Neurodegenerative Disease

Steve Finkbeiner, MD, PhD
Gladstone Institute of Neurological Disease and USCF

4:10 – 4:50 p.m.

Retinal Cell Therapy Using iPS Cells

Masayo Takahashi, MD, PhD
RIKEN Center for Developmental Biology

Final Remarks

Deepak Srivastava, MD
Shinya Yamanaka, MD, PhD