Stem Cells in Focus

    • 27 October, 2017

    CRISPR, CAR-T, and Cancer

    Researchers around the world have long sought effective treatments for cancer, and are now seeing therapeutic benefit with a new treatment, which is demonstrating better than imagined success in patients with blood cancer.
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    • 3 October, 2017

    Organoids: Advancing Regenerative Medicine

    A patient’s fate may lie within a single cell. Therapeutic fate, that is. Scientists can pluck a lone cell, or just a few, out of a patient’s body, grow them in a petri dish, and coax them to form so-called organoids, three-dimensional miniature versions of the original tissue or organ that can be grown indefinitely in the lab.
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    • 11 August, 2017

    Advocates: Moving the Field Forward in Many Ways

    The progress and outcomes of new treatments are important to us all, but arguably no one is more invested in the discovery of new therapies than patient advocate groups. Made up of passionate individuals who voluntarily organize to advocate on behalf of those with a particular disease or disorder, these ‘disease advocates’ dedicate their lives to bringing positive changes for others, sometimes including their families and themselves.
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    • 1 May, 2017

    Making Sense of Disease – In a Dish

    Stem cell research is revolutionizing the way scientists study human disease in many ways. One of the most fascinating, is through the creation of human “diseases in a dish,” which are giving scientists a better way to study disease biology and test new drugs. Read how Dr. Kevin Eggan from the Harvard Stem Cell Institute is using this technology to better understand diseases such as amyotrophic lateral sclerosis (ALS) and schizophrenia.
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    • 17 April, 2017

    Stem Cells May Be Key to Curing Retinal Disease

    A team of UK stem cell scientists, led by Dr. Robin Ali from UCL Institute of Ophthalmology in London, has developed a new strategy for repairing the retina by transplanting photoreceptor cells generated in the laboratory from embryonic stem cells. There is a good precedent for using stem cell therapy to repair eye damage. Transplanting corneal stem cells to repair chemical burns of the cornea has been very successful in restoring vision. But the retina – a multi-layered neural network – is a much more complicated structure, so repairing it poses greater challenges.
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    • 17 April, 2017

    Ramping up Discovery with Kidney Organoids

    Although they conjure up images of science fiction, organoids are actually the quirky new name for mini, lab-grown models of human organs. Scientists are using pluripotent stem cells – the master cells that make any cell in the body – to create small buds of brain, thymus, liver, intestine, eye or kidney tissue that replicate some of the functions we find in these organs.
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    • 17 April, 2017

    October 8 is Stem Cell Awareness Day

    The ISSCR celebrates Stem Cell Awareness Day on October 8 with a Stem Cells in Focus webcast entitled “The Science of Regenerative Medicine,” presented by PhD candidate Ben Paylor of the Canadian Stem Cell Network. The webinar will explore the basics of stem cell biology and will include three StemCellShorts*, voiced by stem cell experts Drs. Jim Till, Janet Rossant and Mick Bhatia, as well as a question and answer period.
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    • 17 April, 2017

    Q&A: Stem Cells, Regenerative Medicine and Veterans

    This week, nations around the world recognize Remembrance Day and Veterans Day. The ISSCR is proud of the role stem cell research is playing in advancing the field of regenerative medicine, which stands to benefit wounded servicemen and women. Dr. Anthony Atala, director of Wake Forest Institute for Regenerative Medicine, North Carolina, U.S.A., leads the consortium of researchers that make up the Armed Forces Institute of Regenerative Medicine (AFIRM). We spoke with him about the organization, which is working to develop advanced treatment options.
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    • 17 April, 2017

    Malaria-in-a-Dish Paves the Way for Better Treatments

    Massachusetts Institute of Technology (MIT) researchers have discovered a new way to model malaria using stem cells in a petri dish, which will allow them to test potential antimalarial drugs and vaccines.
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    • 17 April, 2017

    Introducing A Closer Look at Stem Cells

    Today, we welcome you to the blog’s new home, the expanded Closer Look at Stem Cells website (www.closerlookatstemcells.org). The website is a perfect complement to the “Stem Cells in Focus” blog, housing informational pages on basic stem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditions.
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    • 17 April, 2017

    What to Consider: Human Genome Germline Modification

    In the past few days, you may have heard about new research describing the editing of the DNA sequence in human embryos. This new research raises critical scientific, social, legal and ethical questions to be addressed by all of us.
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    • 17 April, 2017

    Newly Discovered STAP Cells Explained

    You may have heard the news this week about exciting new developments in the field of stem cell research, published in the January 30 issue of Nature. A Japanese scientist, Dr. Haruko Obokata, and her colleagues demonstrated a new way to reprogram specialized stem cells from a newborn mouse to a “pluripotent” state; which is to say, the cells gained the ability to turn into any sort of cell in the body, much the same way embryonic stem cells can. Learn more about this discovery and its potential implications.
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    • 17 April, 2017

    Stimulating The Body's Stem Cells to Treat Multiple Sclerosis

    What if, in this dawning era of regenerative medicine, we could help the body heal itself? Not by replacing diseased or damaged cells, as is so often the paradigm in this field, but by stimulating the stem cells already present in a given tissue to differentiate and then repair the damage. No, this isn’t science fiction, like using one of Dr. McCoy’s futuristic devices from Star Trek to heal the injured Captain Kirk. This approach is now being assessed as a potential treatment for multiple sclerosis.
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    • 17 April, 2017

    An Exciting Strategy for Treating Sickle Cell Disease with Stem Cells

    Stem cell researchers are getting closer to a new treatment for sickle cell disease, moving promising laboratory research into human clinical trials. Millions of people worldwide suffer from this hereditary disease.
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    • 17 April, 2017

    Public Symposium: Stem Cells and the Aging Brain

    At the ISSCR public symposium in Stockholm, stem cell scientists from Germany, Sweden and the U.S. will explore during a moderated panel discussion the role of stem cells in the brain during our lives from development and through adulthood. Panelists will discuss how scientists are investigating what happens to these cells as we age, how this knowledge is being used to guide new strategies to boost brain health and to develop therapies utilizing stem cells to treat diseases of the brain.
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    • 17 April, 2017

    Modeling Human Biology and Organoids: A Big Impact from a Miniature Tissue

    Organoids, or miniature organs, are a relatively new model system that has emerged from stem cell research and are making a big impact. These laboratory-grown, three-dimensional, mini-organs are microscopically small and are started from stem cells. Within a specialized growth environment, the stem cells, either adult or embryonic, depending on the tissue needed, are stimulated to grow and specialize into specific types of organoids. Although they are not exact replicas of the adult organ, they do replicate many aspects and thus give us a model of human development that we would not otherwise have.
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    • 17 April, 2017

    Stem Cell Research: Promise, Progress & Hype

    Summary of a panel discussion at the recent annual meeting of the International Society of Stem Cell Research in Stockholm, featuring international experts discussing the complex issues surrounding the sale and marketing of experimental stem cell treatments.
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    • 17 April, 2017

    The Importance of Professional Guidelines

    Professional guidelines provide a practical and ethical framework for decision making and instill a sense of responsibility and accountability. Learn more about the ISSCR's guidelines for stem cell research and clinical translation.
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    • 17 April, 2017

    Stem Cells Need Sleep, Too

    Sleep is important for our body. With modest sleep deprivation it can be a struggle to function at our highest level and long term sleep deprivation, or disruption, can have significant health effects. It turns out that your sleep deprivation may also impact others…....if you are donating your hematopoietic stem cells.
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    • 17 April, 2017

    Modeling the development and disease of the human enteric nervous system takes guts… and stem cells

    Question: What part of the nervous system has over 500 million neurons - the cells that transmit electrical or chemical signals throughout the nervous system and beyond - and regulates important bodily functions? Sounds like the brain, right? What if you knew that this part of the nervous system also spans approximately 30 feet in an average adult? That’s right, it’s the enteric nervous system (ENS). Never heard of it?
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