The Science and Ethics of Human Brain Organoid Research
Rapid developments in human brain organoid research are likely to produce tractable new bioengineered tools for understanding functional interconnectivity of the human brain and dysfunction involved in many neurodegenerative diseases. Despite the excitement surrounding this subfield of stem cell research and its considerable scientific promise, advances could also raise novel ethical concerns. As researchers generate evermore realistic organoids that resemble human brains in vitro, it is critically important to understand what ethical boundaries may exist and where researchers and regulators should draw the line for research. In this focus session, panelists will discuss scientific, ethical, and policy issues surrounding the use of human pluripotent stem cells to generate self-organizing brain organoids and assembloids for research.
Tools for Basic and Applied Stem Cell Technology
Presented by COREdinate Group (ThermoFisher and Stem Cell Technology)
Stem Cell COREdinates (www.COREdinates.org) is a consortium of human pluripotent stem cell-focused cores that share expertise with protocols, reagents, and technological advancements to establish “best practices". The first part of our Focus session will have selected presentations from Stem Cell COREdinate members. These presentations will cover a number of different areas of expertise including reprogramming, gene editing, disease modeling, and biobanking. The second part of the session will focus on advances in gene editing and cell therapies.
Practical Considerations and Solutions in the Preclinical Development of Investigational Stem Cell Products
Human stem cell products have the potential to treat and prevent many diseases and there are growing research and development efforts underway to make next-generation stem cell therapies a reality. However, there are numerous scientific and regulatory considerations and challenges to address in the development of these investigational products, beginning in the preclinical phase prior to testing in humans. This Focus Session will present practical insights into key scientific and regulatory aspects of preclinical development for an investigational stem-cell product to justify it as safe and efficacious– critical elements of a regulatory submission to initiate human clinical studies.
Translating Your Discovery: From the Laboratory to Industry