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Plenary Roundtables
The Fascination with Gastrulation: The Applications and Ethics of Modeling Early Development
The general public often has concerns about modeling human embryo development in vitro. Are these concerns justified? How might we use this knowledge to translate to tissues valuable for in vivo use? This panel will explore these issues.
Monday, 21 June | 11:45 - 12:45 EDT
Moderator: Janet Rossant, PhD, FRS, FRSC
Gairdner Foundation/The Hospital for Sick Children, Canada
Matthias P. Lutolf, Dipl Ing E
Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Susanne Van Den Brink, PhD
Hubrecht Institute, Netherlands
Insoo Hyun, PhD
Case Western Reserve University School of Medicine and Harvard Medical School, USA
Susana Chuva de Sousa Lopes, PhD
Leiden University Medical Center, Netherlands
Stem Cell Organoid Models as Empirical Testbeds for Personal Medicine Development
Cystic fibrosis is fatal hereditary disease but for some patients, their symptoms can be relieved and life prolonged by certain drugs. These are costly however and only patients with certain genetic mutations are eligible. How can we identify others that may benefit without unnecessary inclusion of non-responders? Stem cell organoid models represent one possible answer. The scientific, clinical, patient, and regulatory aspects of this issue will be considered by the panel that includes the experts and a patient whose life was saved by the “organoid assay”.
Tuesday, 22 June | 11:00 - 11:45 EDT
Moderator: Hans Clevers, MD, PhD
Hubrecht Institute, Netherlands
Kors van der Ent, MD, PhD
UMC Utrecht, Netherlands
Jeffery Beekman, PhD
UMC Utrecht, Netherlands
Els van der Heijden
Stupers Consultancy, Netherlands
Engineered Tissues: Challenges to Bring to Clinic
Regenerative medicine restoring organ function may benefit by pre-organizing tissues from stem cells prior to transplantation. How will the challenges in manufacturing complex bioengineered products for clinical trials and beyond be addressed? Biologists, engineers, and regulatory experts will discuss the complex aspects of the topic.
Saturday, 26 June | 11:00 - 11:45 EDT
Moderator: Lorenz Studer, MD
Sloan-Kettering Institute for Cancer Research, USA
Jennifer Lewis, ScD
Harvard University, USA
Kapil Bharti, PhD
National Institutes of Health (NIH), USA
Wolfram Zimmermann, MD
University Medical Center Goettingen, Germany
Deborah Hursh, PhD
Food and Drug Administration, USA