Stay Connected and Current with ISSCR News, Journals and Blogs
The ISSCR offers access to highly curated, timely news and on-demand science. Read and submit articles on breakthrough science and commentaries about important issues facing the field in Stem Cell Reports, the ISSCR’s open-access, peer-reviewed journal. Stay current with The Pulse, our monthly e-newsletter featuring field-wide news, selected highlights from the stem cell literature, featured job postings, funding resources, and more. And visit A Closer Look at Stem Cells, our public-facing website that provides visitors unbiased, scientifically vetted resources to share with educators, friends and family, and patients.
Human pluripotent stem cell-derived RPE cells extend apical membrane processes that ensheath photoreceptor outer segments and fragment them prior to internalization in a MERTK-dependent manner.
Almedawar et al.
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On the cover: In this issue, Joost et al. (441–457) present a detailed molecular atlas of mouse skin during hair growth and rest. The globe symbolizes the molecular mapping of tissue landscapes. Each circle on the globe illustrates a single cell, with similar colors denoting similar transcriptomes. The Arctic Circle represents the interfollicular epidermis and connects the large continent (a hair follicle actively producing hair) with the small continent (a hair follicle in rest). The article covers how epithelial stem and progenitor cells (dark green) mature and form the hair shaft (yellow) and how the diversity of stromal cells (blue ocean) changes during growth and rest. Cover artwork by Tina Jacob.
Joost et al.
In Fukunaga et al., the image shows immunohistochemistry for CX26 and SOX2 in mouse cochlea and differentiated cells from 2D culture. (A‐C) Staining for CX26 (green), SOX2 (red), and DAPI (blue) in 16‐week mouse cochlea. Heterogeneous SOX2‐positive regions include inner sulcus cells (ISC). IHC, inner hair cells. (D‐I) Staining for CX26 (green), SOX2 (red), and DAPI (blue) in 2D culture at day 15. Heterogeneous SOX2‐positive regions include iCx26GJCs. (G‐I) show magnifications of boxed regions in (D‐F), respectively. Arrowheads point to GJPs. Scale bars: 20 µm (D‐F), 10 µm (A‐C), and 5 µm (G‐I).
Fukunaga et al.