Practical Advice for Physicians and Ethics / Institutional Review Committees
With stem cell science rapidly progressing toward medical application, the number of clinical trials using stem cell-derived approaches is increasing, yet physicians and ethics / institutional review boards currently have little independent guidance on how to assess them. Stem cell-derived cellular interventions require a unique set of considerations that differ from those used to assess pharmacological drugs, so it’s essential that the physicians that run them and the ethics / institutional review boards that approve them are familiar with the appropriate questions to ask. The ISSCR's "Stem Cell-Based Clinical Trials: Practical Advice for Physicians and Ethics/Institutional Review Committees" provides background and fundamental questions for clinicians and ethics / institutional review committees to ask when considering running or reviewing early phase, cell-based clinical trials. The guide was developed by practicing physician-scientists and stem cell professionals on the ISSCR’s Clinical Translation Committee.