New Podcast Episode. Two Decades of iPS Cells: Perspectives from the Field

In 2006, Kazutoshi Takahashi and Shinya Yamanaka at Kyoto University published their landmark paper showing that mouse skin cells could be reprogrammed to an embryonic-like state using just four transcription factors. Over the past two decades, this finding has taken the field of stem cell research in many new directions, opening new ways to study human development, understand and engineer cell fate, model disease, and explore new stem cell–based approaches to medicine. As part of the 20th anniversary celebration of induced pluripotent stem (iPS) cells, we invite leaders in the field to reflect on how the discovery of iPS cells has impacted their own research and the field of stem cell research and its applications more broadly. Together, their stories offer personal insights into how iPS cells have changed stem cell research forever.

Guests

  • Laurent David, Ph.D., Nantes Université, CHU Nantes, Inserm, France 

  • Wei Li, Ph.D., State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, China

  • Sonja Schrepfer, M.D., Ph.D., Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, USA 

Supporting Content: Voices: What impact has iPSC technology had on your research and/or field?, Stem Cell Reports, October 2026

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