ISSCR News
New Podcast Episode. Building a Better Barrier: Modeling the Human gut Epithelium
The human intestinal epithelial barrier comprises diverse proliferative, secretory and absorptive cell types that facilitate nutrient digestion and absorption and protect against harmful environmental agents. The barrier and its function can vary between individuals due to genetic differences thus impact processes such as digestion, drug metabolism, and drug sensitivity. Our guests today investigated the effect of diverse culture conditions on the cell type composition, gene expression profiles, and maturation status of human pluripotent stem cell-derived intestinal epithelial cells in three different model systems. Their research provides insight into the relevant conditions and systems for modeling specific intestinal functions and highlights the importance of personalized intestinal model systems.
The ISSCR Guide To Stem Cell Treatments Now Available in Portuguese
The ISSCR is now pleased to make the Guide to Stem Cell Treatments available in Portuguese. The comprehensive resource is designed to empower patients, advocates, healthcare providers, friends, and family members with the necessary information to make well-informed decisions regarding stem cell treatments, alongside their primary care physicians or specialists.
The translation of this guide was provided by Inês Figueira, José Manuel Inácio, Liliana Bernardino, Ana Paula Terrasso, Susana Solá, Maria Arez and João Camões dos Santos.
The new version is available for download and sharing is encouraged to help raise awareness and understanding of stem cell treatments. Together, we can contribute to the safe and effective delivery of the potential that stem cell research holds for patients worldwide.
New Podcast Episode. Crossing the Border: Modeling the Blood Brain Barrier
The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based models using brain endothelial cells are a powerful tool to investigate how disease-related conditions might affect the blood-brain barrier integrity. However, the cell type composition is critical to faithfully model transcytosis across the blood-brain barrier. Our guests today developed a blood-brain model using induced pluripotent stem cells (iPSCs)-derived endothelial cells with brain-specific identity. Using this model they were able to investigate how disease risk factors affect intracellular transport and reveal a new role for ApoE4 in the regulation of iron metabolism at the blood-brain barrier.
ISSCR Guide To Stem Cell Treatments Now Available in Brazilian Portuguese
The ISSCR is now pleased to make the Guide to Stem Cell Treatments available in Brazilian Portuguese. The comprehensive resource is designed to empower patients, advocates, healthcare providers, friends, and family members with the necessary information to make well-informed decisions regarding stem cell treatments, alongside their primary care physicians or specialists.
Professor Brings Global Stem Cell Medicine Course to PhD Scholars in Pakistan
Dr. Asmat Salim, a faculty member at the University of Karachi, recently adapted the ISSCR’s continuing education course, Stem Cell Medicine: From Scientific Research to Patient Care, into a three-week interactive program for 34 Ph.D. students. Combining lectures, discussions, quizzes, and student presentations, the course provides a strong foundation in stem cell medicine while fostering critical thinking and collaboration.
Students described the program as “highly informative, engaging, and inspiring,” highlighting that it opened new research directions and offered “valuable insights into how stem cells hold potential for treating diseases.”
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