ISSCR News
ISSCR Joins Coalition Effort to Support Advocacy for NIH Funding
The ISSCR is proud to join a broad coalition of scientific societies in affirming the essential role of the National Institutes of Health in advancing biomedical discovery and sustaining a robust research enterprise. As part of this effort, ISSCR members in the targeted states of Kansas, North Carolina, Pennsylvania, and Utah have been invited to share stories that illustrate the vital importance of research investment. Additional opportunities for members in all states will be available in September. This campaign is led by our alliance partner, Research!America.
The ISSCR and Novo Nordisk Foundation Collaborate to Host the Society’s 2028 Annual Meeting in Copenhagen
The International Society for Stem Cell Research (ISSCR) is proud to announce a collaboration with the Novo Nordisk Foundation to host the ISSCR Annual Meeting in Copenhagen, Denmark 27-30 June 2028.
The ISSCR Annual Meeting embodies the mission of both world-class organizations, supporting new frontiers in rigorous science to better human health. The conference is a revered global forum for stem cell science and regenerative medicine, uniting researchers, clinicians, industry leaders, and policy makers from more than 80 countries.
The ISSCR Calls for Science Serving the Public Good to be of the Highest Quality and Integrity
“The ISSCR joined more than 90 scientific, academic, and professional organizations to emphasize that science serving the public good should be of the highest quality, integrity, and utility. In a letter sent to White House Office of Science and Technology Policy Director Michael Kratsios, signatories urged policymakers to recognize that any efforts to strengthen scientific integrity, including those outlined in the recent Executive Order “Restoring Gold Standard Science”, must build upon, rather than undermine, the existing foundational pillars of gold standard science that have driven decades of scientific and technological progress. These principles, including empirical rigor, objectivity, peer review, and reproducibility have been central to the advancement of stem cell science and the development of cell-based therapies.
The ISSCR Responds to ICH’s Q1 Guideline on Stability Testing of Drug Substances and Drug Products
On 28 July, the ISSCR submitted a response to the International Council for Harmonisation’s (ICH) guideline on stability testing of drug substances and drug products. The ISSCR recommends adding specific examples to clarify appropriate applications of certain studies and incorporating considerations for diverse manufacturing models, particularly decentralized manufacturing, where products are administered immediately after production. The ISSCR also advises including guidance on pluripotent stem cell bank stability testing, referencing Tissue Engineered Products (TEP), and clarifying whether ATMP combined products are covered under the term “combination of a drug product with a medical device.”
To request the comments or learn more, contact Denise de Villa.
Alzheimer’s Disease Pathology and Potential Treatment Targets Identified in Brain Organoids
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people, affecting up to 1 in 20 individuals aged 65 and above. In addition to environmental and lifestyle factors, genetic mutations can predispose an individual to AD and some rare forms of inherited “familial” AD (fAD) are caused by known genetic mutations, with these affected individuals developing AD with high probability and at relatively young age. In most cases, AD is diagnosed at advanced stages, but pathological alterations in brain cells may arise earlier in life, particularly in fAD which is known to manifest earlier in life.
To study early-life changes in fAD brain cells, researchers including Zhen-Ge Luo and colleagues from ShanghaiTech University, China, have leveraged stem cell-derived brain organoids, to model aspects of early human brain development and function in the laboratory.
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