ISSCR News
Stem Cells at the Root of Tooth Aging
With age, teeth get increasingly brittle and susceptible to damage from tooth decay, which can eventually lead to tooth loss. Teeth have an intrinsic capability to regenerate, a process which is driven by dental pulp stem cells (DPSCs) which replenish the dental pulp including the dentin-producing cells called odontoblasts. DPSCs stops working in aging teeth, divide less, and generate less odontoblasts, a process which is called senescence or the biological process of aging through gradual deterioration. DPSC senescence is thought to be a cause for the declining tooth health with age.
ISSCR Consortium Urges FDA to Maintain Flexible, Science-Driven Framework for New Approach Methodologies in Drug Development
The International Society for Stem Cell Research (ISSCR) Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development has submitted comments to the U.S. Food and Drug Administration (FDA) in response to the agency’s draft guidance, General Considerations for the Use of New Approach Methodologies in Drug Development Guidance for Industry.
The consortium, a global collaboration of academic scientists, industry leaders, and regulatory experts convened by the ISSCR, welcomed the FDA’s efforts to advance the integration of new approach methodologies (NAMs) into drug development while emphasizing the importance of maintaining a flexible, fit-for-purpose regulatory framework that can adapt to rapidly evolving technologies.
The World’s Most Groundbreaking Stem Cell Advances Are Coming to San Francisco for ISSCR 2027
The International Society for Stem Cell Research (ISSCR) today announced that the ISSCR 2027 Annual Meeting is coming back to San Francisco, USA, 15-18 June 2027. Recognized as the premier international forum for stem cell science, the gathering will recognize 25 years of discovery, collaboration, and progress in stem cell science and gather the people, ideas, and work that will shape the next quarter century.
Natural Component from Licorice Alleviates Inflammatory Bowel Disease in Stem Cell-based Model and in Animals
A new study published today in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.
The burden of IBD is rising globally, with an estimated 4 million people affected worldwide. The disease is characterized by chronic inflammation of the intestinal wall, leading to symptoms such as persistent diarrhea, abdominal pain, and fatigue. Standard treatments include anti-inflammatory drugs and other immune-targeting therapies, but many patients experience only limited benefit.
The Stem Cell Report Podcast Celebrates Five Years with Special Anniversary Episode
New episode revisits leading voices and major advances featured on the podcast
The International Society for Stem Cell Research (ISSCR) today announced the release of a special anniversary episode of The Stem Cell Report podcast, “Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations,” marking five years of exploring the science, people, and stories shaping the field. The podcast features work that has published in the ISSCR’s journal, Stem Cell Reports.
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