ISSCR News

The ISSCR Joins Letter Expressing Concerns Regarding Executive Order on Federal Grantmaking
The ISSCR joined more than 50 scientific societies to send a letter to U.S. congressional leaders expressing concerns over provisions in the recent Executive Order (EO) titled “Improving Oversight of Federal Grantmaking.” The letter details how E.O. provisions threaten the long-standing merit-based peer review system that has been the gold standard for supporting cutting-edge research and driving technological innovation. Provisions the letter highlights include those on shifting the review and selection of research awards to political appointees, expansion of “termination for convenience” authority over awarded grants, vague language regarding repeat grant recipients, and the prioritization of institutions with the lowest indirect cost rates. The letter urges Congress to provide necessary oversight at scientific agencies to prevent potentially significant damage to the federal scientific grantmaking process.

The ISSCR Endorses Joint Associations Group Letter Calling for Continued Support of Essential Research Costs
The ISSCR joined over 160 biomedical and other research organizations to urge U.S. House and Senate appropriators to ensure that essential costs of research continue to be adequately supported by the federal government. These costs, currently collectively known as “indirect costs” or “facilities and administrative” support, are essential to performing high quality scientific research and include expenses like physical lab maintenance, utility costs, data processing, and regulatory compliance. The letter urges appropriators to preserve federal support for essential research expenses, to block arbitrary caps on these costs, and to ensure there is a sufficient transition period for agencies and institutions to make necessary changes to effectively transition to any alternative funding model.

ISSCR Statement on the Scientific and Therapeutic Value of Human Fetal Tissue Research
The International Society for Stem Cell Research (ISSCR), the largest professional organization of stem cell researchers from around the world, is concerned about a recent statement attributed to NIH that the agency will not renew research grants involving human fetal tissue (HFT), and that research with HFT is not conducted responsibly or transparently. In fact, research with HFT has been indispensable in advancing biomedicine and saving millions of lives, and it continues to play an essential role in accelerating research that benefits patients.

The ISSCR Partners with Nuffield Council on Bioethics to Compile Global Horizon Scan on Stem Cell Research
The International Society for Stem Cell Research (ISSCR) today announced a new partnership with the Nuffield Council on Bioethics (NCOB) to conduct an ambitious international horizon scan focused on the future of stem cell science and its ethical implications. The initiative will help signal and inform updates to the ISSCR Guidelines for Stem Cell Research and Clinical Translation and guide the Society’s broader public policy agenda.

The ISSCR Holds Inaugural Regulatory Meeting with Japan’s Pharmaceuticals and Medical Devices Agency and South Korea’s Ministry of Food and Drug Safety
On 7 November 2024, the International Society for Stem Cell Research (ISSCR) held its first meeting with Japan’s Pharmaceuticals and Medical Devices Agency (PMDA) and Korea’s Ministry of Food and Drug Safety (MFDS). Held at PMDA’s Tokyo headquarters, the meeting brought together senior officials from PMDA and MFDS alongside ISSCR leaders based in Japan, Korea, and the United States.
At this inaugural meeting, participants convened to discuss key topics related to the:
1) manufacture of human Pluripotent Stem Cell (hPSC) banks as starting materials for allogeneic, PSC-based therapies, and
2) genetic assessment of hPSCs, 3) jurisdictional differences in guidelines for biological Ancillary Materials (AM).
The participants also had the opportunity to gain insights into the regulatory approaches of the PMDA and MFDS regarding PSC-based products.

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