The Stem Cell Report with Martin Pera
Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Martin Pera, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Pera goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.
Season 1
Episode 1
Blastoids, Gastruloids, and Stem Cell-Based Embryo Models
Guests
Janet Rossant, PhD, Hospital for Sick Children, the University of Toronto and the Gairdner Foundation
Patrick Tam, PhD, University of Sydney, Australia
Featured Paper
Opportunities and Challenges with Stem Cell-Based Embryo Models
Episode 2
The Renaissance of Developmental Biology
Guests
Lorenzo Orietti, PhD, Medical Advisor, Onco-Hematology Unit, Amgen, Inc, (Italy)
Marta Shahbazi, PhD, MRC Laboratory of Molecular Biology, Cambridge, UK
Magdalena Zernicka-Goetz, PhD, Mammalian Embryo and Stem Cell Group and The Centre for Trophoblast Research, University of Cambridge, UK and the California Institute of Technology, USA
Featured Paper
Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis
Episode 3
Stem Cells: From Cancer Vaccines to Space Research
Guests
Joseph Wu, MD, PhD, Director of the Stanford Cardiovascular Institute, USA
Xiaoming Ouyang, PhD, Postdoctoral Scholar, Wu Laboratory, Stanford University, USA
Featured Paper
Anti-Tumor Effects of iPSC-Based Cancer Vaccine in Pancreatic Cancer
Episode 4
Curbing Unproven Stem Cell-Based “Treatments”
Guests
Mohamed Abou-El-Enein, MD, PhD, MSPH, Keck School of Medicine, University of Southern California, USA
Zubin Master, PhD, Mayo Clinic, USA
Kirstin Matthews, PhD, Baker Institute for Public Policy, Rice University, USA
Sean Morrison, PhD, Children’s Research Institute, UT Southwestern, USA
Featured Paper
Unproven Stem Cell Interventions: A Global Public Health Problem Requiring Global Deliberation
Episode 5
Transcription Factor Dance Party - Building Dopaminergic Neurons
Sponsored by bit.bio
Guests
Marius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University
Yi Han Ng, PhD, Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine and Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore
Featured Paper
Efficient Generation of Dopaminergic Induced Neuronal Cells with Midbrain Characteristics
Episode 6
Hans’ Iliad: Troy, Adult Stems, and the Epithelia
Sponsored by Bio-Techne
Guests
Hans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator. Both in the Netherlands.
Kai Kretzschmar, PhD, is junior group leader at the MSNZ University Hospital Würzburg, Germany
Featured Paper
Troy/Tnfrsf19 Marks Epidermal Cells that Govern Interfollicular Epidermal Renewal and Cornification
Episode 7
The Intersection of Stem Cells and Engineering
Guests
Peter Loskill, PhD, W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS)
Christine Mummery, PhD, Professor of Developmental Biology at Leiden University Medical Center and heads the iPSC & organ on a chip facility at the LUMC. She is also the recent past president of the ISSCRF
Featured Papers
Special Issue: Organs-on-Chip
Episode 8
Mending a Broken Heart
Guests
Charles Murry, MD, PhD, University of Washington and Sana Biotechnology
Kenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System
Featured Papers
Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes
Episode 9
Linking Genetic Variants to Cell Phenotypes in Human iPSCs
Guests
Fiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London
Alice Vickers, PhD, INKEF Capital, Amsterdam (current affiliation). Centre for Stem Cells and Regenerative Medicine, King’s College London (previous affiliation).
Featured Papers
Plating Human iPSC Lines on Micropatterned Substrates Relevels Role for ITGBI nsSNV in Endoderm Formation
Episode 10
Breathing Easier – Stem Cells and Lung Function
Guests
Shimpei Gotoh, MD, PhD, Kyoto University
Takahiro Suezawa, PhD, Kyorin Pharmaceutical Company
Carla Kim, PhD, Boston Children’s Hospital and Harvard Medical School
Featured Paper
Disease Modeling of Pulmonary Fibrosis Using Human Pluripotent Stem Cell-Derived Alveolar Organoids
Episode 11
When ROCK Stops the Roll: Explaining the Aging Neural Stem Cell Niche
Guests
Sally Temple, PhD, Neural Stem Cell Institute
Xiuli Zhao, PhD, Neural Stem Cell Institute
Elizabeth Fisher, PhD, Neural Stem Cell Institute
Episode 12
Keeping the Is(lets) on the Prize: Treating T1D with Stem Cell-based Transplants
Guests
Douglas Melton, PhD, Harvard University
Nayara Leite, PhD, Vertex Pharmaceuticals
Featured Papers
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro