The Stem Cell Report with Martin Pera

Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Martin Pera, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Pera goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.

Season 1

Episode 1
Blastoids, Gastruloids, and Stem Cell-Based Embryo Models

Janet Rossant, PhDHospital for Sick Children, the University of Toronto and the Gairdner Foundation
Patrick Tam, PhDUniversity of Sydney, Australia

Featured Paper
Opportunities and Challenges with Stem Cell-Based Embryo Models

Episode 2
The Renaissance of Developmental Biology

Lorenzo Orietti, PhD, Medical Advisor, Onco-Hematology Unit,  Amgen, Inc, (Italy)
Marta Shahbazi, PhDMRC Laboratory of Molecular Biology, Cambridge, UK
Magdalena Zernicka-Goetz, PhDMammalian Embryo and Stem Cell Group and The Centre for Trophoblast Research, University of Cambridge, UK and the California Institute of Technology, USA

Featured Paper
Embryo Size Regulates the Timing and Mechanism of Pluripotent Tissue Morphogenesis

Episode 3
Stem Cells: From Cancer Vaccines to Space Research

Joseph Wu, MD, PhD, Director of the Stanford Cardiovascular Institute,  USA
Xiaoming Ouyang, PhD, Postdoctoral Scholar, Wu Laboratory, Stanford University, USA

Featured Paper
Anti-Tumor Effects of iPSC-Based Cancer Vaccine in Pancreatic Cancer


Episode 4
Curbing Unproven Stem Cell-Based “Treatments”

Mohamed Abou-El-Enein, MD, PhD, MSPH, Keck School of Medicine, University of Southern California, USA
Zubin Master, PhD, Mayo Clinic, USA
Kirstin Matthews, PhD, Baker Institute for Public Policy, Rice University, USA
Sean Morrison, PhD, Children’s Research Institute, UT Southwestern, USA

Featured Paper
Unproven Stem Cell Interventions: A Global Public Health Problem Requiring Global Deliberation


Episode 5
Transcription Factor Dance Party - Building Dopaminergic Neurons
ponsored by

Marius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University

Yi Han Ng, PhD, Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine and Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore

Featured Paper
Efficient Generation of Dopaminergic Induced Neuronal Cells with Midbrain Characteristics 


Episode 6
Hans’ Iliad: Troy, Adult Stems, and the Epithelia
Sponsored by Bio-Techne

Hans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator. Both in the Netherlands. 

Kai Kretzschmar, PhD, is junior group leader at the MSNZ University Hospital Würzburg, Germany 

Featured Paper
Troy/Tnfrsf19 Marks Epidermal Cells that Govern Interfollicular Epidermal Renewal and Cornification

Episode 7
The Intersection of Stem Cells and Engineering

Peter Loskill, PhD, W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS)

Christine Mummery, PhD, Professor of Developmental Biology at Leiden University Medical Center and heads the iPSC & organ on a chip facility at the LUMC. She is also the recent past president of the ISSCRF

Featured Papers
Special Issue: Organs-on-Chip

Episode 8
Mending a Broken Heart

Charles Murry, MD, PhD, University of Washington and Sana Biotechnology

Kenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System

Featured Papers
Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

Episode 9
Linking Genetic Variants to Cell Phenotypes in Human iPSCs

Fiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London

Alice Vickers, PhD, INKEF Capital, Amsterdam (current affiliation). Centre for Stem Cells and Regenerative Medicine, King’s College London (previous affiliation).

Featured Papers
Plating Human iPSC Lines on Micropatterned Substrates Relevels Role for ITGBI nsSNV in Endoderm Formation

Episode 10
Breathing Easier – Stem Cells and Lung Function

Shimpei Gotoh, MD, PhDKyoto University
Takahiro Suezawa, PhDKyorin Pharmaceutical Company
Carla Kim, PhDBoston Children’s Hospital and Harvard Medical School

Featured Paper
Disease Modeling of Pulmonary Fibrosis Using Human Pluripotent Stem Cell-Derived Alveolar Organoids

Episode 11
When ROCK Stops the Roll: Explaining the Aging Neural Stem Cell Niche

Sally Temple, PhDNeural Stem Cell Institute

Xiuli Zhao, PhDNeural Stem Cell Institute

Elizabeth Fisher, PhDNeural Stem Cell Institute

Featured Papers
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway