ISSCR Remembers Sir John Gurdon
The International Society for Stem Cell Research (ISSCR) joins the global scientific community in mourning the loss of Nobel Laureate Professor Sir John Gurdon, whose visionary discoveries forever changed our understanding of biology and inspired generations of scientists around the world.
Professor Gurdon’s pioneering nuclear transfer experiments in frogs answered one of the most fundamental questions in biology, whether specialized cells retain the full genetic blueprint of life. His landmark demonstration that the nucleus of a mature cell could direct the development of an entire organism laid the foundation for fundamental advances in stem cell science.
His groundbreaking work paved the way for the discovery of cellular reprogramming and the development of induced pluripotent stem cells (iPSCs), achievements recognized with the 2012 Nobel Prize in Physiology or Medicine, shared with Dr. Shinya Yamanaka, a former president of the ISSCR.
“Sir John Gurdon’s elegant experiments fundamentally changed how we think about cell identity and potential,” said ISSCR President Hideyuki Okano. “His discoveries on reprogramming and pluripotency by nuclear transfer opened the door to new areas of stem cell research, inspiring countless scientists, including many members and leaders within the ISSCR, to pursue new frontiers in understanding and treating human disease. His legacy is nothing short of transformative, and his influence will continue to guide the field for generations to come.”
A devoted mentor, colleague, and leader, Professor Gurdon shaped not only a field but a global community of scientists who carry forward his vision of understanding life through the lens of cellular potential. His enduring influence is woven into the very fabric of stem cell science, and the impact of his insights continues to shape biomedical research across fields ranging from regenerative medicine and genetics to cancer biology and reproductive science.
The ISSCR is hosting an international symposium in Kyoto, Japan, in October 2026 to commemorate the Nobel Prize-winning discovery. The event will bring together scientists from around the world to showcase breakthrough research influenced by Professor Gurdon’s and Professor Yamanaka’s work and explore the next generation of innovations in stem cell science poised to advance human health.
Learn more about Professor Gurdon’s legendary career in a 2019 interview with Shinya Yamanaka conducted by Deepak Srivastava at the ISSCR 2019 Annual Meeting.
The photo of Sir John Gurdon is credited to The University of Cambridge, UK.