New Podcast Episode. Born Without a Nose

Announcements
Written By Megan Koch

Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today investigated the developmental basis of this distinct defect using induced pluripotent stem cells (iPSCs) derived from patients with BAMS. They assessed the differentiation potential of BAMS patient-derived iPSCs into cranial placode cells, a group of progenitor cells that contribute to the formation of the nasal epithelium. This allowed them to study the behavior of the nasal epithelial cells during early development. Their work uncovered cellular mechanisms underlying BAMS and provided new insights into the developmental processes that shape the human nose. 

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Guests

  • Shifeng Xue, National University of Singapore, Singapore

  • Vanitha Venkoba Rao, National University of Singapore, Singapore

Supporting Content: Cranial placode differentiation defect in individuals born without a nose, Stem Cell Reports

Megan Koch
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