With age, teeth get increasingly brittle and susceptible to damage from tooth decay, which can eventually lead to tooth loss. Teeth have an intrinsic capability to regenerate, a process which is driven by dental pulp stem cells (DPSCs) which replenish the dental pulp including the dentin-producing cells called odontoblasts. DPSCs stops working in aging teeth, divide less, and generate less odontoblasts, a process which is called senescence or the biological process of aging through gradual deterioration. DPSC senescence is thought to be a cause for the declining tooth health with age. 

A new study published today in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.

‍The burden of IBD is rising globally, with an estimated 4 million people affected worldwide. The disease is characterized by chronic inflammation of the intestinal wall, leading to symptoms such as persistent diarrhea, abdominal pain, and fatigue. Standard treatments include anti-inflammatory drugs and other immune-targeting therapies, but many patients experience only limited benefit.

New episode revisits leading voices and major advances featured on the podcast

‍The International Society for Stem Cell Research (ISSCR) today announced the release of a special anniversary episode of The Stem Cell Report podcast, “Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations,” marking five years of exploring the science, people, and stories shaping the field. The podcast features work that has published in the ISSCR’s journal, Stem Cell Reports.

The International Society for Stem Cell Research (ISSCR) announces that Stem Cell Reports, its official open-access, peer-reviewed journal, has been named the official journal of the BaCell 3D Organoid Conference, taking place 22-24 June 2026 in Basel, Switzerland.

‍BaCell 3D brings together leading scientists, innovators, and industry experts at the forefront of organoid technologies, microphysiological systems, and disease modeling. Held annually in one of Europe’s most vibrant life science hubs, the meeting fosters global collaboration and accelerates advances in in vitro multicellular systems that are transforming biomedical research.