ISSCR News
Cloaked Stem Cells Evade Immune Rejection in Mice, Pointing to a Potential Universal Donor Cell Line
A study published today in Stem Cell Reports demonstrates that genetically engineered human pluripotent stem cells (hPSCs) can overcome immune rejection in mice with humanized immune systems, surviving for five months in a stringent transplantation model. The findings provide proof-of-principle for the development of a potential universal donor hPSC line designed to resist immune attack.
mRNA Therapy Restores Fertility in Genetically Infertile Mice
Researchers have found that targeted delivery of messenger RNA (mRNA) can restore sperm production and fertility in genetically infertile male mice. The findings, published today in Stem Cell Reports, demonstrate that transient mRNA treatment restored sperm production and enabled the birth of healthy offspring.
New Podcast Episode. Illuminating hPSC-derived Sensory Neurons
Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were once difficult to obtain. Our guests today focus on improving the derivation and study of sensory neurons, which are sparse and diverse nerve cells near the spine that carry information like pain, touch, or position of the body to the brain. Damage to these neurons or sensory neuropathies, as can happen in diabetes or infections, is estimated to affect millions of people worldwide, yet treatments are limited. To improve the generation of human sensory neurons, the authors developed a genetic toolkit to fluorescently label these individual cells and their subtypes. This approach enables more precise study of these subtypes, their roles in disease, and potentially the development of treatments for sensory neuropathies.
Two Early Career Editors Join the Stem Cell Reports Editorial Board, Expand Scientific Expertise and Global Reach
Stem Cell Reports, the peer-reviewed, open-access journal of the International Society for Stem Cell Research (ISSCR), today announced the appointment of two new Early Career Editors – Bo Shen, Ph.D., Principal Investigator at the National Institute of Biological Sciences, Beijing (NIBS) and Assistant Professor at Tsinghua University, China; and Luca Peruzzotti-Jametti, M.D., Ph.D., Clinical Principal Research Associate at the Department of Clinical Neurosciences, and Group Leader at the MS Society Cambridge Centre for Myelin Repair (CCMR) at the University of Cambridge; and Honorary Senior Lecturer, Department of Metabolism, Digestion and Reproduction, Imperial College London, UK.
New Study Shows Gut Microbiota Directly Regulates Intestinal Stem Cell Aging
A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline. The results were published today in Stem Cell Reports.
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