ISSCR News
Rat Kidneys Grown in Mice Offer New Insights into Addressing Organ Donor Shortages
In a study published today in Stem Cell Reports, Shunsuke Yuri of the National Center for Geriatrics and Gerontology, Japan and Ayako Isotani of the Nara Institute of Science and Technology, Japan, successfully generated rat-derived kidneys in mice using a technique known as interspecies blastocyst complementation. The researchers created mouse embryos genetically unable to form kidneys, leaving a developmental niche that could be filled by injected embryonic stem cells. When rat embryonic stem cells were introduced into these embryos, they contributed extensively to kidney formation, particularly to nephron progenitor cells and ureteric bud lineages, resulting in the generation of a rat cell-derived kidney.
Stem Cell Reports Welcomes Five New Early Career Editors
Stem Cell Reports, the official journal of the International Society for Stem Cell Research (ISSCR), today announces the appointment of five new Early Career Editors to its editorial team. Representing institutions across North America, Europe, Asia, and Australia, the new editors bring broad expertise spanning developmental biology, neuroscience, genetics, cancer biology, cardiovascular biology, stem cell-based disease modeling, and emerging applications of stem cell engineering in cellular agriculture.
The newly appointed Early Career Editors are:
Alessandro Bertero, University of Turin, Italy
Conchi Estaras, Temple University, USA
Lachlan Harris, QIMR Berghofer Medical Research Institute, Australia
Caroline Pearson, Weill Cornell Medicine, USA
Shifeng Xue, National University of Singapore
The ISSCR Celebrates Martin Pera for Transformative Leadership and Lasting Contributions to Stem Cell Reports as he Steps Down from the Journal’s Editorial Team
The International Society for Stem Cell Research (ISSCR) and Stem Cell Reports are celebrating the remarkable contributions of Martin Pera as he concludes his long tenure with the journal following years of leadership that helped shape Stem Cell Reports into a leading voice in stem cell science and regenerative medicine.
Stem Cells at the Root of Tooth Aging
With age, teeth get increasingly brittle and susceptible to damage from tooth decay, which can eventually lead to tooth loss. Teeth have an intrinsic capability to regenerate, a process which is driven by dental pulp stem cells (DPSCs) which replenish the dental pulp including the dentin-producing cells called odontoblasts. DPSCs stops working in aging teeth, divide less, and generate less odontoblasts, a process which is called senescence or the biological process of aging through gradual deterioration. DPSC senescence is thought to be a cause for the declining tooth health with age.
ISSCR Consortium Urges FDA to Maintain Flexible, Science-Driven Framework for New Approach Methodologies in Drug Development
The International Society for Stem Cell Research (ISSCR) Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development has submitted comments to the U.S. Food and Drug Administration (FDA) in response to the agency’s draft guidance, General Considerations for the Use of New Approach Methodologies in Drug Development Guidance for Industry.
The consortium, a global collaboration of academic scientists, industry leaders, and regulatory experts convened by the ISSCR, welcomed the FDA’s efforts to advance the integration of new approach methodologies (NAMs) into drug development while emphasizing the importance of maintaining a flexible, fit-for-purpose regulatory framework that can adapt to rapidly evolving technologies.
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