Appendix 2: Nomenclature Criteria

Acceptance Criteria

Appropriate nomenclature is critical to the unambiguous identification of cell materials used in stem cell research. Adherence to general principles for naming cell lines and attention to issues that impact robustness is essential in generating consistent, easily employed nomenclature to identify materials. Ideally, assigned nomenclature should adhere to the following standards.

GENERAL PRINCIPLES

  • Nomenclature should provide informative code to generate persistent and unique identifier

  • Identifier should be linked to donor and STR profile (authentication)

  • Identifier should allow to trace clones and derivatives to source

  • Free to generate (for example, by API)

  • Free to access and referenced in a central registry

  • Consistent across publishers and journals

  • Machine readable and if possible human readable

  • Fit on standard tube labels (14-18 symbols)

  • Linked to authentication profiles

  • Allow FAIR data principle application (findable, accessible, interoperable and reusable)

ROBUSTNESS

  • Automation of nomenclature generation (hPSCreg)

  • Automated authentication test and match/mismatch recognition (donor/stem cell line/clones and derivatives)

  • Link to and harmonizing with related codes (RRID)

  • Sufficient scalability

The ISSCR's Standards for Human Stem Cell Use in Research are strictly copyrighted by the society. No part of this document may be produced in any form without written permission of The International Society for Stem Cell Research. Contact isscr@isscr.org for more information.

©2023 by The International Society for Stem Cell Research. All rights reserved.

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Appendix 1: Recommended Standard Characterization of Stem Cells

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Appendix 3: Cell Culture Hygiene Practices